肿瘤代谢介导的免疫逃逸及血管生成研究进展

Study on advances of tumor metabolites mediating immune escape and angiogenesis

肿瘤的病程进展是一个多因素相互影响的动态过程,肿瘤细胞以其独特的代谢方式,在满足自身快速增殖需要的同时,促进抑制性免疫细胞浸润及肿瘤血管生成,从而影响肿瘤免疫逃逸,促进肿瘤转移。肿瘤细胞异常的糖、脂、氨基酸及能量代谢产物与免疫异常及血管病变密切相关,是近年来该领域的研究热点。本文综述了肿瘤代谢产物对肿瘤免疫、病理性血管生成的影响及分子机制,为以代谢为靶标的肿瘤治疗提供潜在靶点。

The progression of tumor is a dynamic process of multiple factors interacting with each other.With its unique metabolic method,tumor cells meet their own rapid proliferation needs while promoting inhibitory immune cell infiltration and tumor angiogenesis,thereby affecting tumor immune escape,promoting tumor metastasis.Abnormal glucose,lipids,amino acids and energy metabolites of tumor cells are closely related to immune abnormalities and vascular diseases,which are the research hotspots in this field in recent years.This article reviews the effects of tumor metabolites on tumor immunity and pathological angiogenesis and its molecular mechanisms,which provides the potential targets for tumor therapy with metabolism as a target.