CCR5在神经系统疾病中作用的研究进展

Research progress of CCR5 in nervous system diseases

目前对神经系统疾病发生机制的诸多新发现为研发防治神经系统疾病的药物提供了更多的靶点,其中CCR5是趋化因子CC家族成员CCL3、CCL4和CCL5的受体,已成为神经系统疾病的重要治疗靶点,其天然存在的突变体CCR5△32对多种神经系统疾病显示出保护作用,具有重要的医学价值。CCR5的生物学作用在中风、阿尔茨海默病、多发性硬化等神经系统疾病中的研究也越来越多。已有数种CCR5抑制剂作为神经保护药物开展临床试验。因此,本文主要对CCR5治疗神经系统疾病的研究进展做一综述,以期为CCR5抑制剂用于神经系统疾病的治疗提供依据。

At present,many new discoveries on the pathogenesis of nervous system diseases provide more targets for the research of drugs that treat nervous system diseases.CCR5 is the receptor of CCL3,CCL4 and CCL5,members of the chemokine CC family,and has become an important therapeutic target for nervous system diseases.CCR5△32,as a natural mutation of CCR5,has shown protective effect on a variety of nervous system diseases and has important medical value.The biological role of CCR5 in stroke,Alzheimer’s disease,multiple sclerosis and other neurological diseases has been increasingly studied.Several CCR5 inhibitors have been tested in clinical trials as neuroprotective agents.Therefore,this paper mainly reviews the research progress of CCR5 in the treatment of neurological diseases,in order to provide evidence for the use of CCR5 inhibitors in the treatment of neurological diseases.