替硝唑联合克林霉素磷酸酯治疗细菌性阴道炎的效果观察

Effect of tinidazole combined with clindamycin phosphate in the treatment of bacterial vaginitis

目的探索替硝唑口服联合克林霉素磷酸酯阴道凝胶局部外用治疗细菌性阴道炎的临床疗效,并观察治疗后对复发率和致病菌检出率的影响。方法将98例细菌性阴道炎患者随机分为观察组(48例)和对照组(50例)。对照组给予替硝唑口服治疗,观察组再增加克林霉素磷酸酯阴道凝胶局部涂抹治疗。比较两组患者临床总有效率、临床症状消失时间、不良反应发生率、治疗前后病原菌和乳杆菌属检出率及复发率。结果对照组临床总有效率和复发率分别为74和14%,观察组分别为93.75%和4.17%,差异均有统计学意义(P<0.05)。治疗后两组不良反应发生率差异无统计学意义(P>0.05)。治疗后观察组黏膜充血、外阴阴道疼痛、外阴瘙痒及白带消失时间均比对照组短(P<0.05),病原菌检出率明显低于对照组(P<0.05)。结论替硝唑口服联合克林霉素磷酸酯阴道凝胶局部外用治疗细菌性阴道炎临床疗效显著,值得推广应用。

Objective To explore the clinical efficacy of tinidazole combined with Clindamycin Phosphate Vaginal Gel topical application in the treatment of bacterial vaginitis,and observe the recurrence rate and the detection rate of pathogenic bacteria after treatment.Methods Ninety-eight cases of bacterial vaginitis were randomly divided into observation group(48 cases)and control group(50 cases).The control group was given tinidazole orally,while the observation group was treated with Clindamycin Phosphate Vaginal Gel local smear.The clinical total effective rate,disappearance time of clinical symptoms,incidence of adverse reactions,detection rate of pathogenic bacteria and Lactobacillus before and after treatment and recurrence rate were compared between the two groups.Results The clinical total effective rate and recurrence rate of the control group were 74%and 14%,respectively,and those of the observation group were 93.75%and 4.17%,respectively,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups after treatment(P>0.05).After treatment,mucosal congestion,vulvovaginal pain,vulvar pruritus and leucorrhea disappearance time of the observation group were shorter than those of the control group(P<0.05),and the detection rate of pathogenic bacteria was significantly lower than that of the control group(P<0.05).Conclusion Tinidazole orally combined with topical Clindamycin Phosphate Vaginal Gel is effective in the treatment of bacterial vaginitis.It is worthy of popularization and application.