摘要
目的:评估妊娠期糖尿病(GDM)对双胎妊娠孕妇的母儿围产期结局对双生子12月龄内生长发育的影响。方法:采用巢式病例对照研究,根据口服葡萄糖耐量试验(OGTT)结果,将研究对象分为GDM组和无GDM组(Non-GDM组),记录并描述两组间的围产期结局以及双生子0~12月龄的生长情况。结果:总计507例双胎妊娠孕妇被纳入研究,其中GDM组137例和Non-GDM组370例。GDM组的孕妇比Non-GDM组的年龄更大(29.9岁vs 28.9岁)、体质量指数(BMI)更高(22.2 kg/m^(2) vs 20.8 kg/m^(2)),差异有统计学意义(P<0.05)。GDM组的妊娠期高血压疾病(HDCP)的发生率高于Non-GDM组,差异有统计学意义(10.9%vs 4.6%,P<0.05)。两组其他围产期结局差异无统计学意义(P>0.05)。总计257例双生子从出生随访到12月龄,包括GDM组85例和Non-GDM组172例。随访期间GDM组双生子超重发生比率与Non-GDM组比较,差异无统计学意义(P>0.05);在纠正月龄3月和6月后,GDM组双生子肥胖发生比率明显高于Non-GDM组(P<0.05)。结论:双胎妊娠孕妇GDM的HDCP发生率较高,其双生子半岁内肥胖的发生率也较高,其他的母婴围产期结局无显著差异。
Objective:To evaluate the influence of gestational diabetes mellitus on perinatal outcomes and growth profiles from birth to 12 months in twins.Methods:A nested case-control study was conducted in 507 twin pregnancies.These women were categorized into GDM group and Non-GDM group according to their OGTT results.erinatal outcomes including pregnancy complications and growth profiles of twins from birth to 12 months were collected by follow up.Results:507 twin pregnancies were finally enrolled in the analysis.Women in GDM group had older age(median 29.9 vs.28.9,P<0.001)and higher body mass index(median 22.2 kg/m^(2) vs.20.8 kg/m^(2),P<0.05)than those in Non-GDM group.The incidence of hypertensive disorder complicating pregnancy(HDCP)in GDM group was also higher than Non-GDM group(10.9%vs.4.6%,P<0.05).The differences in other perinatal outcomes between the two groups were not statistically significant(P>0.05).There were 257 cases of twins had been followed-up for 12 months including 85 GDM cases and 172 Non-GDM cases.The incidence of overweight was not significantly different between the 2 groups during the one-year follow-up except for the corrected age of 3 month and 6 month.Conclusions:Compared to non-GDM,both the incidence of HDCP and obesity within half a year in their twin children were higher in twin pregnancies with GDM,with no significant differences in other maternal and infant perinatal outcomes.
作者
刘天骄
梅又文
樊欣
赵妍
乔娟
文利
余莲
王岚
彭方亮
刘亚敏
童超
漆洪波
LIU Tianjiao;MEI Youwen;FAN Xin(Department of Obstetrics,the First Affiliated Hospital of Chongqing Medical University,International Collaborative Jointed Laboratory of Maternal and Fetal Medicine,Ministry of Education,Chongqing Medical University,Sate Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality,Chongqing 400016,China;Department of Child Health Care,Chongqing Health Center for Women and Children,Chongqing 401147,China)
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2021年第5期358-363,共6页
Journal of Practical Obstetrics and Gynecology
基金
国家自然科学基金(编号:81520108013)。
关键词
妊娠期糖尿病
双胎妊娠
围产期结局
生长发育
Gestational diabetes mellitus
Twin pregnancies
Perinatal outcome
Growth profiles