丁苯酞注射液联合对症治疗对OCSP分型急性脑梗死患者血清IMA、LP-PLA2水平的影响

Effect of butylphthalide injection combined with symptomatic treatment on serum IMA and LP-PLA2 levels in patients with acute cerebral infarction of OCSP type

目的探究丁苯酞注射液联合对症治疗对卒中研究分型(oxfordshire community stroke study classification,OCSP)急性脑梗死患者血清缺血修饰蛋白(ischemia modifying protein,IMA)、脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,LP-PLA2)水平的影响.方法选取成都市郫都区人民医院神经内科收治的急性脑梗死患者219例.采用随机数字表法分为观察组(109例)和对照组(110例),均进行OCSP分型.对照组采用对症治疗,观察组在对照组基础上加用丁苯酞注射液.治疗2个月,观察两组IMA和LP-PLA2水平、神经功能缺损情况和日常生活能力、两组临床疗效、两组相同OCSP分型IMA和LP-PLA2水平.结果观察组治疗后IMA、LP-PLA2水平低于对照组(P<0.05).观察组治疗后美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分低于对照组,Barthel指数高于对照组(P<0.05).治疗后观察组IMA、LP-PLA2水平低于对照组(P<0.05),观察组与对照组完全前循环梗死亚型(total anterior circulation infarct,TACI)、部分前循环梗死亚型(partial anterior circulation infarct,PACI)、后循环梗死亚型(posterior circulation infarct,POCI)、腔隙性脑梗死亚型(Lacunar infarction,LACI)中IMA、LP-PLA2水平依次下降(P<0.05);且观察组TACI、PACI、POCD、LACD分型IMA、LP-PLA2水平低于对照组TACI、PACI、POCD、LACD分型(P<0.05).两组无明显不良反应发生.结论丁苯酞注射液联合对症治疗可有效改善OCSP分型急性脑梗死患者血清IM A水平、LP-PLA2水平、神经功能缺损情况,提高日常生活能力;且对于OCSP分型中TACI患者疗效更好,.

Objective To investigate the effect of butylphthalide injection combined with symptomatic treatment on the levels of serum ischemia-modified albumin(IMA)and 1 lipoprotein-associated phospholipase A2(LP-PLA2)in patients with acute cerebral infarction by Oxfordshire Community Stroke Project(OCSP).Methods Two hundred and nineteen patients with acute cerebral infarction admitted to our neurology department were enrolled and randomLy divided into observation group(109 cases)and control group(110 cases)for OCSP typing.The control group received symptomatic treatment,and the observation group supplemented with butylphthalide injection on the basis of the control group.After 2 months of treatment,the-levels of IMA and LP-PLA2,neurological deficit and daily living ability,clinical efficacy of the two groups,and the same OCSP typing IMA and LP-PLA2 levels were recorded.Results The levels of IMA and LP-PLA2 in the observation group were lower than those in the control group after treatment(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score was lower in the observation group than in the control group,and the Barthel index was higher than that in the control group(P<0.05).The levels of IMA and LP-PLA2 in the observation group were lower than those in the control group after treatment(P<0.05).Both in the observation group and the control group,the IMA and LP-PLA2 levels total anterior circulation infarction(TACI),partial anterior circulation infarction(PACI),and posterior circulation infarction(POCI),lacunar cerebral infarction(LACI)decreased in sequence(P<0.05);the IMA and LP-PLA2 levels in TACI,PACI,POCD,LACD typing were lower in observation group than in control group(P<0.05).No obvious adverse reactions occurred in the two groups.Conclusion Butylphthalide injection combined with symptomatic treatment can effectively improve the serum lM A level,LP-PLA2 level and neurological deficit in patients with acute cerebral infarction by OCSP typing,aswell as the ability of daily life,which has a better effect for TACl patients with adverse reactions occurred.