自噬与支气管肺发育不良关系的研究进展与展望

Recent progress and prospect for the relationship between autophagy and bronchopulmonary dysplasia

支气管肺发育不良(BPD)是早产儿最常见的呼吸系统慢性疾病。BPD的病因和发病机制尚未明确,可能与早产儿肺发育过程停滞有关。自噬是广泛存在的程序性细胞死亡过程,可实现某些细胞器的更新和代谢需求。新近发现,肺发育各阶段均有自噬参与;在BPD的发生过程中,自噬失衡发挥重要作用;合理调控自噬水平可有效改善肺部损伤。现就自噬在BPD发生过程中的作用研究进行综述。

Bronchopulmonary dysplasia(BPD)is a commonly seen chronic lung disease in preterm infants.Although its etiology and pathophysiology have not been fully elucidated,it was thought to cause bronchoalveolar arrest.Autophagy is a certain programmed cell death process,which can achieve the renewal of organelles and metabolic needs.It is reported that autophagy is involved in all stages of lung development during the fetal period.The imbalance of autophagy plays an important role in the process of BPD.Furthermore,the appropriate regulation of autophagy could effectively improve lung injury.Now,the recent advancements of the role of autophagy in BPD is summarized in this review.