血浆正五聚蛋白3与过敏性紫癜关系的研究进展

Research progress on the relationship between pentraxin 3 and Henoch-Schonlein purpura

过敏性紫癜(HSP)是儿童时期最常见的一种以非血小板减少性紫癜为特征性临床表现的系统性小血管炎,主要表现为皮肤紫癜、关节炎、消化道症状和紫癜性肾炎(HSPN)等,肾受累轻重是决定儿童HSP远期预后的主要因素。有研究表明,测定血清中正五聚蛋白3(PTX3)可早期诊断HSPN和预测肾损伤。现对PTX3的来源、基因及蛋白质结构、功能及其与HSP的潜在关系与作用机制进行探讨,以期为HSPN的早期诊断及治疗提供新思路。

Henoch-Schonlein purpura(HSP)is one of the most common clinical manifestations of systemic small vasculitis in children with non-thrombocytopenic,and mainly manifested as skin purpura,arthritis,gastrointestinal symptoms and Henoch-Schonlein purpura nephritis(HSPN).The severity of renal involvement is the main factor determining the long-term prognosis of children with HSP.Studies have revealed that the determination of pentraxin 3(PTX3)in serum can be used for early diagnosis of HSPN and prediction of renal injury.In this paper,the origin,gene and protein structure,function,potential relationship and mechanism of action between PTX3 and HSP were discussed,so as to provide new ideas for the early diagnosis and treatment of HSPN.