2012-2017年常州市武进区肥胖相关癌症发病趋势分析

Incidence Trend of Obesity-Associated Cancers in Wujin District of Changzhou From 2012 to 2017

目的 2012-2017年常州市武进区肥胖相关癌症的发病趋势,为肥胖相关癌症防治提供依据。方法收集常州市武进区2012-2017年肥胖相关癌症发病数据,使用SPSS 17.0软件计算粗发病率、年龄别发病率和中国人口标化率。趋势变化采用年度变化百分率(annual percentage change,APC)及t检验进行分析。结果 2012-2017年常州市武进区新发肥胖相关癌症8 581例,占所有恶性肿瘤新发病例的30.84%,粗发病率为144.58/10万,标化发病率为85.82/10万,粗发病率的APC为10.81%(t=6.96,P<0.05),标化发病率的APC为12.07%(t=9.14,P<0.05),均呈上升趋势。肥胖相关癌症发病率随着年龄增长而增加。其中65~74岁组年均增长为13.72%(P<0.05),增长幅度最大。肥胖相关癌症中食管腺癌标化发病率的APC为-15.48%(P<0.05),呈下降趋势;结直肠癌、胰腺癌、肾癌和甲状腺癌标化发病率的APC分别为10.82%(P<0.05)、7.48%(P<0.05)、13.32%(P<0.05)和30.49%(P<0.05),均呈上升趋势。结论 2012-2017年常州市武进区肥胖相关癌症发病率上升趋势明显,通过生活方式干预控制超重和肥胖有助于降低肥胖相关癌症的发病。

Objective To analyze the incidence trend of obesity-associated cancers in Wujin district of Changzhou from 2012 to 2017 so as to provide the evidence for the prevention and treatment of obesity-associated cancers. Methods Data about incidence of obesity-associated cancers were collected in Wujin District of Changzhou from 2012 to 2017. The crude incidence, age-specific incidence, age-standardized rate by Chinese standard population(ASR China) were calculated by using SPSS17.0 software. Annual percentage change(APC) and t tests were used for trend analysis. Results A total of 8 581 new cases of obesity-associated cancers were diagnosed in Wujin district of Changzhou from 2012 to2017, accounting for 30.84% of all cancers diagnosed. The crude incidence rate and the ASR China of obesity-associated cancers were144.58/105 and 85.82/105, and the corresponding APC of crude and standardized incidence were10.81%(t=6.96,P<0.05) and 12.07%(t=9.14,P<0.05),respectively. Age-specific incidence of obesity-associated cancers increased with age. The APC of incidence in the 65-74 age group was13.72%(P<0.05),with the largest increase. The APC of ASR China for esophageal adenocarcinoma was-15.48%(P<0.05), showing a decreasing trend. The APC of ASR China for colorectal cancer,pancreatic cancer,kidney cancer and thyroid cancer was 10.82%(P<0.05),7.48%(P<0.05),13.32%(P<0.05) and 30.49%(P<0.05), respectively, showing an increasing trend. Conclusion The incidence of obesity-associated cancers has increased significantly in Wujin district of Changzhou. Controlling overweight and obesity through lifestyle interventions may help reduce the incidence of obesity-associated cancers.