抑制侵袭性真菌的新型分子及其作用靶点研究进展

Research progress on novel molecules and new targets for the control of invasive fungi

目前药物治疗侵袭性真菌感染受其严重的毒副作用及耐药性菌株等挑战,故研发安全、高效的新型抗真菌药物对于解决现状具有重要意义。本文从侵袭性真菌作用靶点着手,在小分子物质和次生代谢产物等方面挖掘涉及真菌生物膜、细胞壁、关键代谢酶及线粒体等作用靶点及其机制,以期为防治侵袭性真菌的新药研发提供借鉴。

At present,the drug treatment for invasive fungal infection is challenged by serious adverse effects and drug resistance.Therefore,the research and development of safe and effective new antifungal drugs is a great importance to support the clinical treatment of invasive fungal diseases.This article reviewed new targets of invasive fungi,and explores the underlying mechanisms of fungal biofilm formation,cell wall,key metabolic enzymes,mitochondria in the aspects of small molecule inhibitors and secondary metabolites,which may provide reference for the research and development of new drugs.