健脾养胃汤联合参苓全营养制剂在结直肠癌癌性营养不良患者的应用

Application of Jianpi Yangwei Decoction Shenling Combined with Shenling Quanyingyang Mixture in the Treatment of Patients with Colorectal Cancer Induced Malnutrition

目的:探讨健脾养胃汤联合参苓全营养制剂在结直肠癌癌性营养不良患者的应用效果。方法:选取2018年2月至2019年12月宝安纯中医治疗医院收治的营养不良结直肠癌患者106例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组53例。2组患者接受腹腔镜根治术,术后采用FOLFOX方案化疗2个周期,对照组在此基础上给予常规肠内营养支持,观察组给予健脾养胃汤联合参苓全营养制剂,2组均营养支持治疗至化疗结束。观察2组治疗前后营养状况、免疫功能以及化疗疗效和不良反应的差异。结果:2组治疗后白蛋白(ALB)、前白蛋白(PA)、血红蛋白(HGB)、转铁蛋白(TRF)、上臂肌围(AMC)、CD8^(+)较治疗前升高(P<0.05),CD3^(+)、CD4^(+)、CD3^(+)CD16^(+)CD56^(+)较治疗前降低(P<0.05)。观察组治疗后ALB、PA、HGB、TRF、AMC、CD3^(+)、CD4^(+)、CD3^(+)CD16^(+)CD56^(+)高于对照组(P<0.05),CD8^(+)低于对照组(P<0.05)。观察组Ⅲ~Ⅳ度化疗相关不良反应率低于对照组(P<0.05)。结论:与常规肠内营养制剂比较,健脾养胃汤联合参苓全营养制剂可有效改善结直肠癌患者营养状态、提高免疫功能,并能降低不良反应。为结直肠癌临床治疗提供新的思路和方式,值得在临床进一步推广。

Objective:To explore the effect of Jianpi Yangwei Decoction combined with Shenling Quanyingyang Mixture in the treatment of colorectal cancer patients with malnutrition Methods:A total of 106 patients with malnourished colorectal cancer admitted to Bao′an Authentic Traditional Chinese Medicine Therapy Hospital from February 2018 to December 2019 were randomly divided into a control group and an observation group according to table of random digits,with 53 cases in each group.The patients in the 2 groups received laparoscopic radical operation and FOLFOX chemotherapy for 2 cycles.The patients in the control group received routine enteral nutrition support while the patients in the observation group received with Jianpi Yangwei Decoction combined Shenling total nutrition admixture.Both groups received nutrition support treatment until the end of chemotherapy.The nutritional status,immune function,chemotherapy effect and adverse reactions were observed before and after treatment.Results:After treatment,albumin(ALB),prealbumin(PA),hemoglobin(HGB),transferrin(TRF),arm muscle circumference(AMC),CD8^(+)were higher than those before treatment(P<0.05),CD3^(+),CD4^(+),and CD3^(+)CD16^(+)CD56^(+)were lower than those before treatment(P<0.05).After treatment,ALB,PA,HGB,TRF,AMC,CD3^(+),CD4^(+),and CD3^(+)CD16^(+)CD56^(+)in the observation group were higher than those in the control group(P<0.05),and CD8^(+)were lower than those in the control group(P<0.05).The rate ofⅢ-Ⅳdegree chemotherapy-related adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Compared with the conventional enteral nutrition preparation,Jianpi Yangwei Decoction combined with Shenling Quanyingyang Mixture could effectively improve the nutritional status and immune function of colorectal cancer patients,and reduce adverse reactions,which provide new ideas and methods for the clinical treatment of colorectal cancer and is worth further promotion in the clinic.