中医药治疗心力衰竭及其对心肌组织ATP含量影响的研究进展

Research Progress of Traditional Chinese Medicine for the Treatment of Heart Failure and Its Effect on ATP Content of Myocardial Tissue

心肌代谢障碍是心力衰竭(HF)发生发展的重要原因之一。中医药在调节心肌组织代谢方面发挥着重要作用,其机制可能是通过相关中药的有效成分调节心肌细胞ATP酶活性、激活AMPK信号通路、刺激肌酸激酶(CK)反应、提高心肌基质金属蛋白酶(MMP)水平、保护线粒体结构及功能等途径,保证ATP的供应及传递,改善心脏的能量代谢,纠正HF。近年来,中医药治疗慢性HF的优势逐渐突出,并取得良好成果,研究中医药对HF时心肌组织ATP的供应机制,有助于为临床治疗该病提供理论依据。

Myocardial metabolic disorder is one of the important reasons for the development of heart failure.Traditional Chinese medicine(TCM)plays an important role in regulating the metabolism of myocardial tissues,and its mechanism may be to regulate the ATP synthase activity of myocardial cells through the active ingredients of related Chinese medicines,activate Adenosine 5′-monophosphate activated protein kinase(AMPK)signal pathway,stimulate the creatine kinase(CK)response,and increase the level of mitochondrial membrane potential(MMP)in myocardial tissue,protecting the structure and function of mitochondria,ensuring the supply and transmission of ATP,improving the energy metabolism of the heart and correcting heart failure.In recent years,the advantages of TCM for chronic heart failure have gradually become prominent,and good results have been achieved.Studying the mechanism of TCM for the supply of ATP in myocardial tissue during heart failure will help provide a theoretical basis for clinical treatment of the disease.