摘要
单纯疱疹病毒脑炎所引发的自身免疫性脑炎日益受到关注,其发病机制可能与单纯疱疹病毒感染神经元后神经元裂解释放抗原引起免疫反应有关。这种继发性的自身免疫性脑炎临床表现多样,早期容易与复发性单纯疱疹病毒性脑炎相混淆,延误治疗导致严重的神经功能缺损及预后不良。脑脊液和血清中检出自身免疫性脑炎相关抗体则有助于诊断,免疫治疗有效。本文结合相关文献综述了单纯疱疹病毒感染后的自身免疫性脑炎的发展历史、发病机制、临床表现、辅助检查和诊疗流程,为临床医生提供借鉴。
Autoimmune encephalitis caused by herpes simplex virus encephalitis has received increasing attention,the pathogenesis of which may be related to the immune response caused by the release of antigens after the herpes simplex virus infecting neurons.This secondary autoimmune encephalitis has various clinical manifestations,which are easily confused with recurrent herpes simplex virus encephalitis.The delayed treatment may lead to severe neurological deficits and poor prognosis.The detection of autoimmune encephalitis related antibodies in cerebrospinal fluid and serum is helpful for diagnosis.Immunotherapy is effective for autoimmune encephalitis secondary to herpes simplex virus encephalitis.This article reviews the development history,pathogenesis,clinical manifestations,auxiliary examinations,diagnosis,and treatment procedures of autoimmune encephalitis after herpes simplex virus infection.
作者
迟博闻
王佳伟
Chi Bowen;Wang Jiawei(Department of Neurology,Beijing Tongren Hospital,Capital Medical University,Beijing 100073,China;Central Laboratory,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)
出处
《首都医科大学学报》
CAS
北大核心
2021年第3期341-346,共6页
Journal of Capital Medical University
基金
国家自然科学基金面上项目(81771313)
国家自然科学基金青年基金(81301029)
国家科技部重点研发计划(2016YFC0904502)
北京市自然科学基金面上项目(19G11041)
北京市医院管理局“青苗”计划专项(QML20150206)
北京市科技计划课题“首都特色”项目(Z171100001017039)
首都医学发展重点攻关项目(2014-1-1101)。
