摘要
目的:研究老年非小细胞肺癌(NSCLC)患者三维适形放疗联合化疗的疗效及影响因素。方法:回顾性选择2015年1月~2018年10月期间在某院接受三维适形放疗联合化疗的58例局部晚期NSCLC老年患者,评价短期疗效及2年生存率,分析临床病理特征、PCNA及Ki-67表达与疗效的关系。结果:NSCLC患者的治疗缓解率为65.52%、2年总生存率(OS)为46.55%;不同性别、年龄、病灶部位NSCLC患者的治疗缓解率、2年OS无明显差异(P>0.05);不同AJCC分期、病理类型、PCNA及Ki-67表达的NSCLC患者比较,治疗缓解率、2年OS、生存曲线有显著性差异(P<0.05);AJCC分期、病理类型、PCNA及Ki-67表达是治疗缓解率的独立影响因素,而AJCC分期、PCNA及Ki-67表达是2年OS的独立影响因素。结论:局部晚期NSCLC老年患者三维适形放疗联合化疗的疗效与AJCC分期、病理类型、PCNA及Ki-67表达有关。
Objective:To study the efficacy and influencing factors of three-dimensional conformal radiotherapy combined with chemotherapy in elderly patients with non-small cell lung cancer(NSCLC).Methods:58 elderly patients with locally advanced NSCLC who received three-dimensional conformal radiotherapy combined with chemotherapy in a hospital from January 2015 to October 2018 were retrospectively selected.The short-term efficacy and 2-year survival rate were evaluated.The correlation among clinical pathological characteristics,PCNA,Ki-67 expression,and efficacy was analyzed.Results:The treatment remission rate of NSCLC patients was 65.52%,and the 2-year overall survival rate(OS)was 46.55%.There was no significant difference in the treatment remission rate and 2-year OS of NSCLC patients with different gender,age and lesion location(P>0.05).The treatment remission rate,2-year OS and survival curve of NSCLC patients with different AJCC stages,pathological types,PCNA and Ki-67 expression were significantly different(P<0.05).AJCC stage,pathological type,PCNA and Ki-67 expression were independent influencing factors of remission rate,while AJCC stage,PCNA and Ki-67 expression were independent influencing factors of 2 years OS.Conclusion:The efficacy of three-dimensional conformal radiotherapy combined with chemotherapy in elderly patients with locally advanced NSCLC correlates with AJCC stage,pathological type,PCNA and Ki-67 expression.
作者
闻朋浩
张振
李芳芳
张建东
肖聃
Wen Penghao;Zhang Zhen;Li Fangfang;Zhang Jiandong;Xiao Dan(Department of Medical Oncology,Nanshi Hospital Affiliated to Henan University,Nanyang 473065;Department of Medical Oncology,Nanyang No.1 People's Hospital,Nanyang 473000;Department of Radiotherapy,Nanyang No.1 People's Hospital,Nanyang 473000)
出处
《数理医药学杂志》
CAS
2021年第6期794-797,共4页
Journal of Mathematical Medicine
关键词
非小细胞肺癌
三维适形放疗
影响因素
PCNA
KI-67
non-small cell lung cancer
three-dimensional conformal radiotherapy
influencing factors
PCNA
Ki-67