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妊娠期血脂代谢水平、Lp-PLA2与高危妊娠的关系研究 被引量:1

Relationship between Serum Lipid Metabolism,Lp-PLA2 and High-risk Pregnancy
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摘要 目的:分析妊娠期血脂代谢水平、清脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)与高危妊娠的关系。方法:选择高危妊娠患者120例作为研究组,选择同期健康妊娠者120例作为对照组,检测和比较两组患者的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)以及血清Lp-PLA2水平,比较不同组间血脂指标和Lp-PLA2的差异,并通过Logistic法分析高危妊娠以及不良妊娠结局的危险因素。结果:研究组患者的血脂水平和血清Lp-PLA2水平均显著高于对照组(P<0.05);血清TC、TG、HDL-C和Lp-PLA2与高危妊娠评分呈正相关关系(P<0.05);研究组中的120例患者中,共出现87例(72.50%)不良妊娠结局,出现不良妊娠结局的患者的血脂水平和血清Lp-PLA2显著高于未出现不良妊娠结局的患者(P<0.05);Logistic回归分析结果显示TC、TG、HDL-C和Lp-PLA2是高危妊娠以及高危妊娠不良妊娠结局的危险因素(P<0.05)。结论:高危妊娠患者的血脂指标和血清Lp-PLA2水平显著升高,并且TC、TG、HDL-C和Lp-PLA2是高危妊娠以及高危妊娠不良妊娠结局的危险因素。 Objective:To analyze the relationship between serum lipid metabolism,lipoprotein associated phospholipase A2(Lp-PLA2)and high-risk pregnancy.Methods:120 high-risk pregnant patients were selected as the study group,and 120 healthy pregnant women were selected as the control group.Total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C)and low density lipoprotein(LDL-C)and serum Lp-PLA2 levels were measured and compared between the two groups.The differences of blood lipid index and Lp-PLA2 between the groups were compared,and the risk factors of high-risk pregnancy and adverse pregnancy outcome were analyzed by Logistic method.Results:The blood lipid level and serum Lp-PLA2 level in the study group were significantly higher than those in the control group(P<0.05).Serum TC,TG,HDL-C and Lp-PLA2 were positively correlated with high-risk pregnancy scores(P<0.05).Of the 120 patients in the study group,87(72.50%)had adverse pregnancy outcomes.Blood lipid level and serum Lp-PLA2 in patients with adverse pregnancy outcomes were significantly higher in patients without adverse pregnancy outcomes(P<0.05).Logistic regression analysis showed that TC,TG,HDL-C and Lp-PLA2 were risk factors for high-risk pregnancy and adverse pregnancy outcomes in high-risk pregnancy(P<0.05).Conclusion:Serum lipid index and serum Lp-PLA2 levels are significantly elevated in high-risk pregnant patients,and TC,TG,HDL-C,and Lp-PLA2 are risk factors for high-risk pregnancy and adverse pregnancy outcomes in high-risk pregnancy.
作者 卢涛 牛玉玲 Lu Tao;Niu Yuling(Department of Gynaecology,Kaifeng Maternal and Child Health Hospital,Kaifeng 475000)
出处 《数理医药学杂志》 CAS 2021年第6期802-804,共3页 Journal of Mathematical Medicine
基金 国家重点研发计划“精准医学研究”项目(2017YFC0909902)。
关键词 高危妊娠 不良妊娠结局 血脂 代谢 清脂蛋白相关磷脂酶A2 high-risk pregnancy adverse pregnancy outcome blood lipids metabolism lipoprotein associated phospholipase A2
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  • 1俞丽平.上虞市7069例孕产妇高危妊娠管理分析[J].中国公共卫生管理,2013,29(4):548-550. 被引量:6
  • 2高彩凤,丁海霞,刘向明.802例高危孕产妇资料分析[J].中国生育健康杂志,2004,15(5):280-281. 被引量:1
  • 3邓香珠,陈毓芬.2176例高危孕产妇情况分析[J].中国妇幼保健,2005,20(1):50-51. 被引量:5
  • 4徐香芬.永康市2002~2004年高危孕产妇监测情况分析[J].中国妇幼保健,2006,21(2):184-185. 被引量:11
  • 5Nelson SM, Matthews P, Posto L. Matemal metabolism and obesity:modifiable determinants of pregnancy outcome [ J ]. Hum Reprod Update, 2010, 16 (3) : 255-275. DOI : 10.1093/humupd/dmp050.
  • 6Jarvie E, Hauguel-de-Mouzon S, Nelson SM, et al. Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring [ J ]. C lin Sci (Lond), 2010, 119 (Pt 3 ) : 123-129. DOI: 10.1042/CS20090640.
  • 7Kim C. Maternal outcomes and follow-up after gestational diabetes mellitus [ J ]. Diabet Med, 2014, 31 (3) : 292-301. DOI: 10.1111/dme.12382.
  • 8O' Sullivan EP, Avalos G, O' Reilly M, et al. Atlantic Diabetes in Pregnancy (DIP) : the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria[J]. Diabetologia, 2011,54(7) : 1670-1675. DOI: 10.1007/s00125-011-2150-4.
  • 9Bodmer-Roy S, Morin L, Cousineau J, et al. Pregnancy outcomes in women with and without gestational diabetes mellitus according to the international association of the diabetes and pregnancy study groups criteria [J]. Obstet Gynecol, 2012, 120 (4) : 746-752. DOI: 10.1097/AOG.0b013e31826994ec.
  • 10Herrera E, Ortega-Senovilla H. Disturbances in lipid metabolism in diabetic pregnancy-Are these the cause of the problem? [J]. Best Pract Res Clin Endocrinol Metab, 2010, 24 (4) : 515-525. DOI: 10.1016/j.beem.2010.05.006.

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