妊娠期血脂代谢水平、Lp-PLA2与高危妊娠的关系研究

Relationship between Serum Lipid Metabolism,Lp-PLA2 and High-risk Pregnancy

目的:分析妊娠期血脂代谢水平、清脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)与高危妊娠的关系。方法:选择高危妊娠患者120例作为研究组,选择同期健康妊娠者120例作为对照组,检测和比较两组患者的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)以及血清Lp-PLA2水平,比较不同组间血脂指标和Lp-PLA2的差异,并通过Logistic法分析高危妊娠以及不良妊娠结局的危险因素。结果:研究组患者的血脂水平和血清Lp-PLA2水平均显著高于对照组(P<0.05);血清TC、TG、HDL-C和Lp-PLA2与高危妊娠评分呈正相关关系(P<0.05);研究组中的120例患者中,共出现87例(72.50%)不良妊娠结局,出现不良妊娠结局的患者的血脂水平和血清Lp-PLA2显著高于未出现不良妊娠结局的患者(P<0.05);Logistic回归分析结果显示TC、TG、HDL-C和Lp-PLA2是高危妊娠以及高危妊娠不良妊娠结局的危险因素(P<0.05)。结论:高危妊娠患者的血脂指标和血清Lp-PLA2水平显著升高,并且TC、TG、HDL-C和Lp-PLA2是高危妊娠以及高危妊娠不良妊娠结局的危险因素。

Objective:To analyze the relationship between serum lipid metabolism,lipoprotein associated phospholipase A2(Lp-PLA2)and high-risk pregnancy.Methods:120 high-risk pregnant patients were selected as the study group,and 120 healthy pregnant women were selected as the control group.Total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C)and low density lipoprotein(LDL-C)and serum Lp-PLA2 levels were measured and compared between the two groups.The differences of blood lipid index and Lp-PLA2 between the groups were compared,and the risk factors of high-risk pregnancy and adverse pregnancy outcome were analyzed by Logistic method.Results:The blood lipid level and serum Lp-PLA2 level in the study group were significantly higher than those in the control group(P<0.05).Serum TC,TG,HDL-C and Lp-PLA2 were positively correlated with high-risk pregnancy scores(P<0.05).Of the 120 patients in the study group,87(72.50%)had adverse pregnancy outcomes.Blood lipid level and serum Lp-PLA2 in patients with adverse pregnancy outcomes were significantly higher in patients without adverse pregnancy outcomes(P<0.05).Logistic regression analysis showed that TC,TG,HDL-C and Lp-PLA2 were risk factors for high-risk pregnancy and adverse pregnancy outcomes in high-risk pregnancy(P<0.05).Conclusion:Serum lipid index and serum Lp-PLA2 levels are significantly elevated in high-risk pregnant patients,and TC,TG,HDL-C,and Lp-PLA2 are risk factors for high-risk pregnancy and adverse pregnancy outcomes in high-risk pregnancy.