慢阻肺急性加重期患者炎症因子与肺功能的相关性分析

Correlation Analysis of Inflammatory Factors and Lung Function in Patients with Acute Exacerbation of COPD

目的:观察分析慢阻肺(慢性阻塞性肺疾病)急性加重期患者炎症因子与肺功能的相关性。方法:选取某院在2019年1月~2019年12月收治的43例慢阻肺急性加重期患者一般资料作为A组,再选取同期收治的43例慢阻肺稳定期患者一般资料作为B组,再选取43例健康体检者一般资料为C组。采用统计学分析3组研究对象的炎症因子水平以及A组患者炎症因子水平与肺功能之间的相关性。结果:A组FEV1(第1秒用力呼气量)表达水平明显低于B组、C组(P<0.05),A组IL-33(白细胞介素-33)、CRP(C反应蛋白)以及TNF-α(肿瘤坏死因子α)表达水平明显高于B组、C组(P<0.05);相关性分析显示IL-33表达水平、CRP表达水平和TNF-α表达水平与FEV1表达水平呈负相关(P<0.05)。结论:慢阻肺急性加重期患者炎症因子与肺功能密切相关。

Objective:To observe and analyze the correlation between inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods:The general data of 43 patients with acute exacerbation of COPD admitted to a hospital(from January 2019 to December 2019)were selected as group A,the general data of 43 patients with COPD admitted to a hospital during the same period were selected as group B,and then the general data of 43 healthy physical check-up patients in a hospital were selected as group C.The inflammatory factor levels in the three groups and the correlation between inflammatory factor levels and lung function in group A were statistically analyzed.Results:The expression level of FEV1 in group A was significantly lower than that in group B and C(P<0.05),and the expression levels of IL-33,CRP and TNF-α in group A were significantly higher than that in group B and C(P<0.05).Correlation analysis showed that IL-33 expression level,CRP expression level,TNF-expression level and FEV1 expression level were negatively correlated(P<0.05).Conclusion:Inflammatory factors are closely related to lung function in patients with acute exacerbation of COPD.