猪肺磷脂注射液联合氨溴索治疗新生儿呼吸窘迫综合征的效果

Efficacy of poractant alfa injection combined with ambroxol on neonatal respiratory distress syndrome

目的观察猪肺磷脂注射液与氨溴索联合治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法抽取2017年5月至2019年5月于周口市中心医院实施常规治疗+猪肺磷脂注射液治疗的40例NRDS患儿纳入对照组;将同期实施常规基础治疗+猪肺磷脂注射液+氨溴索治疗的42例NRDS患儿纳入观察组,全部患儿治疗资料完整,均在治疗2周后评估疗效。比较两组患儿治疗临床指标(症状缓解时间、机械通气时间、氧疗时间、住院时间及住院费用);全部患者均在治疗前、治疗24 h,接受血气检查,指标包括动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))及动脉二氧化碳分压(PaCO_(2));比较两组患儿并发症(肺出血、气胸、肺炎、颅内出血)发生率。结果观察组治疗总有效率高于对照组(P<0.05);观察组症状缓解时间、氧疗时间、机械通气时间及住院时间短于对照组,住院费用少于对照组(P<0.05);两组治疗24 h SaO_(2)、PaO_(2)水平均较治疗前升高,PaCO_(2)水平较治疗前降低,且观察组SaO_(2)、PaO_(2)水平高于对照组,PaCO_(2)水平低于对照组(P<0.05);观察组并发症总发生率低于对照组(P<0.05)。结论NRDS患者给予猪肺磷脂注射液与氨溴索治联合疗有较好的临床效果,能有效缩短治疗时间,促进患儿恢复,改善血气指标,在一定程度上可减少并发症,提高治疗的整体安全性。

Objective To observe the efficacy of poractant alfa injection combined with ambroxol in the treatment of neonatal respiratory distress syndrome(NRDS).Methods Forty children with NRDS treated with conventional treatment and poractant alfa injection in Zhoukou Central Hospital from May 2017 to May 2019 were selected as control group;42 children with NRDS treated with conventional basic treatment+poractant alfa injection+ambroxol during the same period were selected as observation group.The treatment data of all children were complete,and the curative effect was evaluated after 2 weeks of treatment.The clinical indicators of the two groups’children including symptom relief time,mechanical ventilation time,oxygen therapy time,hospitalization time and hospitalization expenses were compared;all patients received blood gas examination before and 24 hours after treatment,the indicators including arterial oxygen saturation(SaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2));the incidence of complications(pulmonary hemorrhage,pneumothorax,pneumonia,intracranial hemorrhage)was compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05);the symptom relief time,mechanical ventilation time,oxygen therapy time,and hospitalization time of the observation group were shorter than those of the control group,and the hospitalization cost was less than that of the control group(P<0.05);after 24 hours of treatment,the levels of SaO_(2) and PaO_(2) in the two groups were higher than those before treatment,and the level of PaCO_(2) was lower than that before treatment.The SaO_(2) and PaO_(2) levels of the observation group were higher than those of the control group,and the PaCO_(2) level was lower than that of the control group(P<0.05);the total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusions The treatment of NRDS patients with poractant alfa injection combined with ambroxol has a significant effect,which can improve the blood gas index of the child,promote the recovery of the child,shorten the treatment time,and save the medical cost.To a certain extent,it can reduce complications and improve the overall safety of treatment.