中空纤维肿瘤模型研究进展

Research progress of the hollow fiber tumor model

中空纤维肿瘤模型(hollow fiber tumor model)或中空纤维测定法(Hollow Fiber Assay,HFA)是由美国国家癌症研究所(Nationa Cancer Institute,NCI)设计的一种新型抗癌药物初步筛选模型,可以简单快速、准确可行地进行初步体内疗效的评估。近年来已被广泛应用于抗肿瘤药物的研发过程中,并且有了新的改良优化和应用。本文系统综述了中空纤维肿瘤模型在抗肿瘤药物筛选方面的优势特点以及近10年最新应用进展,研究认为,HFA在抗肿瘤药物研究中占据了越来越重要的地位,HFA的改良模型在个体化癌症治疗和机制研究上有着广阔的应用前景。

The hollow fiber tumor model,also known as the hollow fiber assay(HFA),was designed by the US National Cancer Institute for the purpose of evaluating preliminary in vivo drug efficacy in a simple,rapid manner.In recent years,it has been widely used in the research and development of anti-tumor drugs,from which new and improved optimizations and applications have emerged.This paper systematically summarizes the characteristics and advantages of the HFA in anti-tumor drug screening,together with the last 10 years of progress in HFA applications.We anticipate that the HFA will play an increasingly important role in anti-tumor drug research,and the improved model of HFA will have broad applications in research on individualized cancer treatments and mechanistic studies.