氢气生物医学效应的发现、研究与应用

Discovery,research and application of hydrogen biomedical effects

氢气可通过抗炎、抗氧化、抗凋亡、调节能量代谢和生物酶活性等作用机制,在心血管、脑神经、肿瘤等疾病中发挥潜在的保护效应,并在初步的临床试验中取得良好的防治效果。氢气已经作为辅助治疗被列入新型冠状病毒肺炎诊疗方案,在生物医学领域展现出广阔的应用前景。如今,氢气的生物学作用已经得到了广泛的关注,其未知的作用机制也逐渐被发现,但氢气医学的广泛应用还面临许多挑战。本文围绕氢气生物医学效应的发现、多效性作用机制以及临床应用方面进行系统综述,并阐述了目前氢气生物医学研究面临的挑战和应对策略。

Hydrogen has potential protective effects on cardiovascular,brain,tumor and other diseases through anti-inflammatory,anti-oxidation,anti-apoptosis,regulation of energy metabolism and biological enzyme activities,and has achieved preventive and therapeutic effect in preliminary clinical trials.Hydrogen as an supplement treatment has been provided by therapeutic protocols for novel corona-virus pneumonia,and has broad application prospects in the biomedical field.At present,the biological role of hydrogen has been widely concerned,and its unknown mechanism has been gradually discovered.However,the wide application of hydrogen medicine still has many challenges.This review focuses on the discovery of hydrogen biomedical effects,pleiotropic mechanism and clinical application,and describes the challenges and coping strategies of hydrogen biomedical research.