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TMPRSS2 activity may mediate sex differences in COVID-19 severity

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摘要 Dear Editor,Since the initial reports of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection early this year,coronavirus disease 2019(COVID-19)has rapidly reached pandemic levels with high transmissibility and low but significant mortality.While individuals with a number of underlying comorbidities are more likely to develop severe disease,male sex has emerged as an independent risk factor for poor prognosis,an observation that cannot be accounted for by age or social behaviors including smoking.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第4期1095-1097,共3页 信号转导与靶向治疗(英文)
基金 This research was supported in part by grants from the United States Public Health Service(HL141638 to D.O.D.and Al 144529 to D.M.E.).
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