摘要
Dear Editor,COVID-19(Coronavirus Disease-2019),a respiratory disease caused by the novel virus strain,SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),an enveloped,positive-sense,single-stranded RNA betacoronavirus of the family Corona-viridae,has spread worldwide.1 Notably,SARS-CoV-2 infection led to poor induction of typeⅠ interferon response,and the impaired type Ⅰ IFN responses have been shown to be associated with severe COVID-19 disease.2 However,molecular mechanisms by which SARS-CoV-2 suppresses type Ⅰ IFN production,and how host cells respond to the inhibition of type Ⅰ IFN response during SARS-CoV-2 infection,remain largely unknown.
基金
This work was supported by funding from NIH ROI AG047156,ROI All 12844&R01 AI147394(J.S.),and CA 203971(ZL)
This study was partially funded by the Fraternal Order of Eagles Cancer Research Fund(to M.D.)grant number FP00089365.
