微生物群在放疗诱导损伤中的作用研究进展

Research progress on the role of microbiota in radiotherapy-induced injury

人类的微生物群由细菌、病毒、真菌等微生物组成,它们分布于口腔、鼻腔、肠道、阴道、皮肤等部位,并且对宿主的代谢、免疫、激素和稳态功能有着至关重要影响。它既保护宿主和维持体内平衡,又能够引起炎症和肿瘤发生。微生物群已被发现可以调节某些肿瘤化疗和免疫治疗疗效及不良反应,但尚无肿瘤放疗背景下的大型研究。本文对微生物群与患者放疗反应和损伤变化的联系进行总结,以期为患者制订最佳治疗方案,为放疗及其诱导损伤的预防及治疗提供依据。

Human microbiota is composed of bacteria,viruses,fungi and other microorganisms,which are distributed in the oral cavity,nasal cavity,intestine,vagina and skin,etc.Human microbiota plays a pivotal role in the metabolism,immunity,hormones and homeostasis of the host.It can protect the host and maintain the homeostasis,and provoke the incidence of inflammation and tumors.Microbiota has been found to modulate the efficacy and toxicity of chemotherapy and immunotherapy for certain types of tumors.Nevertheless,large-scale studies in the context of radiation therapy have not been performed.In this article,the relationship between the microbiota and the radiotherapy response and toxicity changes of cancer patients was summarized,aiming to develop the optimal treatment plan for patients,and provide evidence for the prevention and treatment of radiotherapy-induced injury.