疏肝化斑汤联合水光针注射治疗黄褐斑临床研究

Clinical Study of Liver-Soothing and Chloasma-Removing Decoction Combined with Water-Light-Needle Injection in the Treatment of Chloasma

目的:观察疏肝化斑汤联合水光针注射治疗黄褐斑的临床疗效。方法:将70例黄褐斑患者按照随机数字表法分为试验组和对照组,每组各35例。两组患者均给予水光针注射疗法,试验组在水光针注射疗法的基础上加用疏肝化斑汤治疗,对照组在水光针注射疗法的基础上加用化瘀祛斑胶囊治疗。比较两组患者的临床疗效及治疗前后皮损评分、中医证候评分、皮肤病生活质量指数(dermatology life quality index,DLQI),测定两组患者治疗前后血清丙二醛(malonaldehyde,MDA)、脂质过氧化物(lipid peroxide,LPO)、超氧化物歧化酶(superoxide dismutase,SOD)水平。结果:两组患者治疗后皮损评分、中医证候评分及DLQI均低于本组治疗前,且试验组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后MDA、LPO低于本组治疗前,且试验组治疗后低于对照组治疗后,两组患者治疗后SOD高于本组治疗前,且试验组治疗后高于对照组治疗后,差异具有统计学意义(P<0.05)。对照组有效率为77.1%,试验组有效率为91.4%,两组有效率比较,差异具有统计学意义(P<0.05)。结论:疏肝化斑汤联合水光针注射治疗黄褐斑,可改善患者的临床症状及生活质量。

Objective:To observe the clinical curative effect of Liver-Soothing and Chloasma-Removing Decoction combined with Water-Light-Needle Injection on chloasma.Methods:A total of 70 patients with chloasma were randomly divided into the experimental group and the control group,with 35 cases in each group.The experimental group was treated with Liver-Soothing and Chloasma-Removing Decoction on the basis of basic treatment,and the control group was treated with Clot-Absorbing and Chloasma-Removing Capsule on the basis of basic treatment.The clinical efficacy,skin lesion score,TCM syndrome score,skin disease quality of life score before and after treatment were compared between the two groups.The levels of serum malondialdehyde(MDA),lipid peroxide(LPO)and superoxide dismutase(SOD)were measured before and after treatment.Results:After treatment,the skin lesion score,TCM syndrome score and skin disease quality of life score of the two groups were lower than those of the same group before treatment,and the above indexes of the experimental group were lower than those of the control group,and all the differences were statistically significant(P<0.05).MDA and LPO of the two groups were lower than those of the same group before treatment,and the above indexes of the experimental group were lower than those of the control group;SOD of the two groups was lower than that of the same group before treatment,and the above index of the experimental group was lower than that of the control group;and all the differences were statistically significant(P<0.05).The effective rate was 77.1%in the control group and 91.4%in the experimental group,and the difference was statistically significant(P<0.05).Conclusion:Liver-Soothing and Chloasma-Removing Decoction combined with Water-Light-Needle Injection can improve the clinical symptoms and quality of life of patients with chloasma.