纤维软骨透明化的研究进展

Research progress of fibrocartilage hyalinization

关节软骨是分布在关节表面的主要组织,在承重和润滑中起着重要作用。四肢关节的关节软骨主要由富含Ⅱ型胶原的透明软骨组成。当软骨损伤或退变时,原有的天然软骨会被富含Ⅰ型胶原蛋白的纤维软骨逐步取代。在此,我们提出一种新的软骨修复策略,该观点的重点是原位纤维软骨的改性和透明软骨的形成,即"纤维软骨透明化"。我们对纤维软骨透明化的可行性和潜在机制进行初步探讨和展望,有望此策略对软骨修复研究的发展和临床转化有一定帮助。

Articular cartilage is a major tissue distributed at the joint surface;it plays a role in load-bearing and lubricating.The articular cartilage of the joints in the extremities mainly consists of hyaline cartilage composed of collagen II.Fibrocartilage formation is easily observed when the cartilage is injured or degenerated,which has abundant type I collagen.In this study,a new viewpoint and concept,focusing on the modification of fibrocartilage in situ approach and regeneration of hyaline cartilage,namely"fibrocartilage hyalinization",was proposed as a practical clinical strategy.We conducted preliminary discussions and prospects on the feasibility and potential mechanisms of fibrocartilage hyalinization.It is hoped that the strategy will be helpful to the development and clinical transformation of cartilage regeneration research.