血清胱抑素C、β_(2)微球蛋白及尿微量白蛋白检测在糖尿病肾病早期诊断中的应用探讨

Application of Serum Cystatin C,β_(2) microglobulin and Urine Microalbumin in the early Diagnosis of Diabetic Nephropathy

目的探讨研究血清胱抑素C(Cys-C)、β_(2)微球蛋白(β_(2)-MG)及尿微量白蛋白(mALB)检测在糖尿病肾病早期诊断中的应用。方法选择该院2019年6月-2020年9月收治的60例早期糖尿病肾病患者,纳入早期DN组,后分别抽出同等例数单纯糖尿病(单纯DM组)、健康受检者(对照组)进行对比,比较3组受检者的Cys-C、β_(2)-MG、mALB变化,以判断上述检测方法的临床价值。结果早期DN组、单纯DM组Cys-C、β_(2)-MG、mALB指标显著高于对照组,差异有统计学意义(P<0.05),早期DN组上述3项指标均高于单纯DM组,差异有统计学意义(P<0.05);早期DN组患者Cys-C、β_(2)-MG、mALB阳性检出率均高于单纯DM组,且DN组指标3项联检阳性检出率高于单项检测检出率,差异有统计学意义(P<0.05)。结论Cys-C、β_(2)-MG、mALB3项指标联合用于糖尿病肾病患者早期诊断中,指标变化明显,能有效诊断其病症,且3项指标联检能显著提高患者阳性检出概率,为尽早确诊患者病情、后续治疗有效性提供科学依据,诊断效果显著。

Objective To study the application of serum cystatin C(Cys-C),β_(2) microglobulin(β_(2)-MG)and urine microalbumin(mALB)in the early diagnosis of diabetic nephropathy.Methods The 60 patients with early diabetic nephropathy admitted to the hospital from June 2019 to September 2020 were selected and included in the early DN group,and then the same number of simple diabetes(simple DM group)and healthy subjects(control group)were selected for comparison,Compare the changes of Cys-C,β_(2)-MG,mALB of the 3 groups of subjects to judge the clinical value of the above detection methods.Results The Cys-C,β_(2)-MG and mALB indexes of the early DN group and the simple DM group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).The above three indexes of the early DN group were higher than those of the simple DM group.The difference was statistically significant(P<0.05);the positive detection rates of Cys-C,β_(2)-MG,and mALB in the early DN group were higher than those in the simple DM group,and the positive detection rates of the three combined tests of the DN group were higher than those in the single test,the difference was statistically significant(P<0.05).Conclusion Cys-C,β_(2)-MG and mALB are used in the early diagnosis of patients with diabetic nephropathy.The indicators have changed significantly and can effectively diagnose their symptoms.The combined inspection of the three indicators can significantly increase the probability of positive detection in patients,which is an early diagnosis.The patient's condition and the effectiveness of follow-up treatment provide a scientific basis,the diagnosis effect is remarkable.