单细胞测序技术在多发性骨髓瘤中的研究进展

Progress of single-cell sequencing in multiple myeloma

多发性骨髓瘤(MM)是一种由单克隆浆细胞异常增殖引起的恶性血液疾病。传统的高通量细胞测序仅仅反应细胞群体的异质性,却忽略单细胞中的遗传信息。单细胞测序技术的发展能够更清楚了解肿瘤和骨髓微环境中的细胞差异,深入探索MM的发病机制,并指导临床治疗。文章综述了单细胞测序技术的最新进展及其在MM发病机制、疾病进展监测、免疫治疗和治疗反应方面的应用。

Multiple myeloma(MM)is a malignant hematological disorder caused by the abnormal proliferation of monoclonal plasma cells.Traditional high-throughput cell sequencing reflects the heterogeneity of cell population,while it ignores the genetic information in single-cell.The development of single-cell sequencing has enabled the access to cell-to-cell variation in tumor and microenvironment of bone marrow,providing a deep understanding of the pathogenic mechanisms of MM and guidance for clinical treatment.This paper reviews the latest progress of single-cell sequencing and its application in disease pathogenesis,monitoring of disease progression,immunotherapy and therapeutic responses of MM.