氢质子磁共振波谱成像技术在创伤性脑损伤后认知障碍中的应用

Application of hydrogen proton magnetic resonance spectroscopy in cognitive impair⁃ment after traumatic brain injury

创伤性脑损伤(TBI)可引起一系列复杂的病理生理过程变化,这些变化包括脑内物质代谢异常,导致机体出现包括头痛、认知、运动和情感障碍等在内的长、短期症状,而认知障碍是阻碍TBI患者日常生活质量恢复和延缓其回归社会的重要因素。氢质子磁共振波谱成像技术(1H-MRS)可对急、慢性脑部损伤患者的脑组织代谢进行非侵入性检测,具有辅助诊断和预测长期功能预后的价值。该文将近年来1H-MRS在TBI后认知障碍中的应用进行总结和展望。

Traumatic brain injury(TBI) can cause a series of complex pathophysiological changes including abnormal metabolism of brain substances,leading to long-and short-term symptoms such as headache,cognitive impairment,motor disturbance,and emotional disorders,while cognitive impairment is an important factor hindering the recovery of the quality of daily life of TBI patients and delaying their return to society.Hydrogen proton magnetic resonance spectroscopy(1 H-MRS)can perform noninvasive detection of brain tissue metabolism in patients with acute or chronic brain injury and has the value of assisting diagnosis and predicting long-term functional prognosis.This article summarizes the current status and prospects of the application of 1 H-MRS in cognitive impairment after TBI.