基于金纳米粒子的光学生物传感方法研究进展

Research Progress in Gold Nanoparticles-based Optical Bio-sensing Methods

光学生物传感是以产生各种光学信号为检测基础的一种微量分析技术,具有操作简便、检测成本低、抗干扰能力强及可实现原位检测等优点,在临床诊断、药物分析、环境监测等领域显示出广阔的应用前景。作为纳米材料重要成员之一的金纳米粒子(AuNPs),因其独特的光学性质被广泛用于光学生物传感方法的构建。该文综述了近年来基于金纳米粒子的光学生物传感方法在分析检测中的研究进展,提出了实际应用中可能存在的问题并对未来发展趋势进行展望。

Optical bio-sensing is a kind of microanalysis technology based on the generation of various optical signals.It has the advantages of simple operation,low detection cost,strong anti-interference ability and in situ detection.It has a broad application prospect in clinical diagnosis,drug analysis,environmental monitoring and other fields.Meanwhile,gold nanoparticles(AuNPs),as a particularly important class of nanomaterials,have been widely used in the construction of optical bio-sensing methods due to their unique optical properties.In this review,the recent progresses of AuNPs-based optical bio-sensing methods are summarized,the possible problems in practical application are proposed,and the future development trend is prospected.