麝香保心丸联合盐酸曲美他嗪缓释片治疗经皮冠状动脉介入治疗术后心绞痛临床研究

Clinical Study on Shexiang Baoxin Pills Combined with Trimetazidine Dihydrochloride Modified Release Tablets for Angina Pectoris After Percutaneous Coronary Intervention

目的:观察麝香保心丸联合盐酸曲美他嗪缓释片治疗经皮冠状动脉介入治疗术(PCI)后心绞痛的临床疗效。方法:选取120例PCI术后发生心绞痛的患者,按随机数字表法分为观察组和对照组各60例。2组患者均给予常规护理,对照组给予盐酸曲美他嗪缓释片治疗,观察组在对照组基础上给予麝香保心丸治疗。比较2组临床疗效,统计治疗前后心绞痛发作次数及持续时间,检测不同时间点心脏射血分数(EF值)。结果:观察组总有效率为98.33%,对照组为88.33%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组心绞痛发作次数、持续时间比较,差异无统计学意义(P>0.05)。治疗后,2组心绞痛发作次数、持续时间均低于治疗前,且观察组心绞痛发作次数、持续时间均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组EF值比较,差异无统计学意义(P>0.05)。治疗1周、4周后,2组EF值逐渐升高,且观察组EF值均高于同时间点对照组,差异有统计学意义(P<0.05)。结论:麝香保心丸联合盐酸曲美他嗪缓释片治疗PCI术后心绞痛患者,可显著改善患者心功能,减少心绞痛发作次数及时间。

Objective:To observe the clinical effect of Shexiang Baoxin pills combined with trimetazidine dihydrochloride modified release tablets for angina pectoris after percutaneous coronary intervention(PCI).Methods:A total of 120 cases of patients with angina pectoris after PCI were selected and divided into the observation group and the control group according to the random number table method,60 cases in each group.Both groups were given routine nursing;the control group was additionally given trimetazidine dihydrochloride modified release tablets,and the observation group was additionally given Shexiang Baoxin pills based on the treatment of the control group.The clinical effect was compared between the two groups.The frequency and duration of angina pectoris seizure before and after treatment were counted.The value of ejection fraction(EF)of the heart at different time points was detected.Results:The total effective rate was 98.33%in the observation group,and 88.33%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the frequency and duration of angina pectoris seizure between the two groups(P>0.05).After treatment,the frequency of angina pectoris seizure in the two groups was lower than that before treatment,and the duration was shorter;the frequency of angina pectoris seizure in the observation group was lower than that in the control group,and the duration was shorter;differences were significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of EF value between the two groups(P>0.05).After one-week and four-week treatment,EF values in the two groups were gradually increased,and the value in the observation group was higher than that in the control group at the same time point,the difference being significant(P<0.05).Conclusion:In the treatment of patients with angina pectoris after PCI,the therapy of Shexiang Baoxin pills combined with trimetazidine dihydrochloride modified release tablets can significantly improve the heart function,lower frequency of angina pectoris seizure,and shorten the duration.