摘要
非洲猪瘟(African swine fever,ASF)作为我国当前最为严重的外来猪病,被列为一类动物传染病。2018年8月沈阳暴发ASF疫情以来,连续不断的感染疫情给我国养猪业造成重创,严重威胁生猪养殖的健康发展。目前针对ASF尚无商品化的疫苗和经济有效的抗病毒药物,猪群一旦感染只能依靠快速扑杀进行防控。从干扰素、抗生素、核苷类似物、植物天然产物及其他可能抗非洲猪瘟病毒制剂的研究现状进行详细概述,以期为抗非洲猪瘟药物的创制提供借鉴及参考。
African swine fever(ASF),the most serious exotic pig disease,is listed as a classⅠanimal disease in China.The continuous infection since the outbreak of ASF in Shenyang on August 2018 is now ravaging the development of China’s pork industry,seriously threating the healthy development of pig breeding.There is no commercialized vaccine or cost-effective antiviral drugs,thus only quick killing is reliable to control the disease once pigs are infected.This review summarized the recent research status of agents including interferons,antibiotics,nucleoside analogues,plant-derived products and other compounds that have been reported to inhibit ASFV replication,aiming to provide theoretical basis and reference for the development of potential anti-ASFV drugs.
作者
赵鸿远
王朝
成温玉
马宁宁
李曼
魏小丽
ZHAO Hong-yuan;WANG Zhao;CHENG Wen-yu;MA Ning-ning;LI Man;WEI Xiao-li(School of Modern Agriculture and Biotechnology,Ankang University,Ankang 725000;Animal Husbandry and Veterinary Bureau of Ankang,Ankang 725000)
出处
《生物技术通报》
CAS
CSCD
北大核心
2021年第5期174-181,共8页
Biotechnology Bulletin
基金
陕西省重点研发计划项目(2020NY-027)
安康市主导产业重大科研攻关项目(AK2019ZD-10)
安康市科技计划项目(AK2019NY-1)
安康学院创新团队项目(2019AKTD05)。
关键词
非洲猪瘟病毒
抗病毒制剂
干扰素
核苷类似物
植物天然产物
African swine fever virus
antiviral agents
interferons
nucleoside analogues
plant-derived products
