生物大分子敷料在慢性创面修复中的应用进展

Research Progress on Biomacromolecules Applied in Chronic Wound Repair

慢性创面具有发病机制复杂、容易复发、治疗时间长、难度大、费用高、致残率较高等特点,对患者的生活质量有严重的负面影响,关于慢性创面的治疗是当今创伤治疗的难题之一。伤口敷料在做创面处理时起关键作用,其中以生物大分子为基质成分的功能敷料尤为引人关注。生物大分子因其良好的生物相容性、可生物降解性、低毒性等生物特性,可以制成针对慢性创面修复的多种形式的生物敷料,并可通过改性或复合的方法,增强其作为敷料的性能。通过对生物大分子相关性质和生物大分子敷料在慢性创面修复中的应用研究进展予以综述,说明了生物大分子敷料在慢性创面修复中有着很大的应用前景,为生物大分子敷料的临床研究提供思路和帮助。

Chronic wounds are characterized by complicated pathogenesis,easy recurrence,long treatment time,great difficulty,high cost and high disability rate which have serious negative impacts on the life quality of patients.The treatment of chronic wounds is one of the difficult problems of wound treatment today.Wound dressings play a key role in wound treatment,especially the functional dressings with biomacromolecules as matrix components.Because of good biocompatibility,biodegradability,low toxicity and other biological characteristics,biomacromolecules can be made into various biological dressings for chronic wound repair,and can be modified or compounded with enhanced performance as a dressing.This article reviewed the research progresses of biomacromolecule-related properties and the applications of biomacromolecule dressings in chronic wound repair.It indicates that biomacromolecule dressings have great application prospects in chronic wound repair,providing ideas and help for clinical research of biomacromolecule dressings.