miRNA27a在恶性肿瘤疾病中的研究进展

Research progress of miRNA27a in malignant tumor diseases

MicroRNAs(miRNAs)是一类非编码小RNA,miRNAs可调节细胞信号传导,调控基因表达,影响细胞增殖、凋亡等多种细胞生理过程,对于维持正常的生物代谢和细胞内环境的稳态发挥了至关重要的作用。此外,miRNAs广泛参与癌症的发生和进展,研究表明,miRNAs家族中的一员miRNA27a,可在不同的癌症疾病模型中发挥癌基因或抑癌基因的作用,本文将对miRNA27a在不同的恶性肿瘤中的表达情况、作用机制以及潜在临床应用作一综述。

MicroRNAs(miRNAs)are a class of non coding small RNAs.MiRNAs can regulate cell signal transduction and gene expression,affect cell proliferation,apoptosis and other cell physiological processes,and play a crucial role in maintaining normal biological metabolism and homeostasis of the intracellular environment.In addition,miRNAs are widely involved in the occurrence and progress of cancer.Studies have shown that miRNA27a,a member of the miRNAs family,can play the role of oncogene or tumor suppressor gene in different cancer disease models.This article will review the expression,mechanism and potential clinical application of miRNA27a in different malignant tumors.