脑心通胶囊+降纤酶对急性脑血栓的治疗有效率及不良反应分析

Analysis of Effective Rate and Adverse Reaction of Naoxintong Capsule+Defibrase in the Treatment of Acute Cerebral Thrombosis

目的脑心通胶囊联合降纤酶对急性脑血栓患者的治疗有效率及不良反应分析。方法便利选择2018年3月—2020年3月该院收治的48例急性脑血栓患者作为研究对象,采用随机数表法分为两组,每组24例。对照组采用静脉滴注降纤酶,观察组在对照组的基础上服用脑心通胶囊。比较两组患者的治疗有效率、不良反应、血液流变学指标以及凝血功能相关指标。结果观察组临床疗效(91.67%)明显优于对照组(66.67%),两组比较差异有统计学意义(χ^(2)=4.547,P<0.05)。治疗后,观察组血液流变学指标中红细胞积压(42.05±7.22)%、血浆粘度(203.08±15.46)mPa·s、血沉(18.35±3.28)mm/h明显优于对照组,两组比较差异有统计学意义(t=4.630、3.380、2.990,P<0.05)。观察组凝血功能相关指标中APTT(22.05±4.22)s、FIB(3.18±0.66)g/L、D-D(186.35±34.28)ng/mL、PT(15.19±1.06)s明显优于对照组,两组比较差异有统计学意义(t=2.051、6.976、3.348、4.721,P<0.05)。观察组不良反应发生率(12.50%)明显优于对照组(37.50%),两组比较差异有统计学意义(χ^(2)=4.000,P<0.05)。结论脑心通胶囊联合降纤酶应用于急性脑血栓临床疗效理想,可以有效改善患者血液流变学指标和凝血功能,不良反应发生率较低,具有较高的临床应用价值,值得推广运用。

Objective To analyze the effective rate and adverse reactions of Naoxintong capsule combined with defibrase in the treatment of patients with acute cerebral thrombosis.Methods 48 patients with acute cerebral thrombosis admitted to the hospital from March 2018 to March 2020 were convenient selected as the research objects,and they were divided into two groups using a random number table method,24 cases in each group.The control group received intravenous infusion of defibrase,and the observation group took Naoxintong capsules on the basis of the control group.The treatment efficiency,adverse reactions,hemorheology indexes and coagulation function related indexes of the two groups of patients were compared.Results The clinical efficacy of the observation group(91.67%)was significantly better than that of the control group(66.67%),and the difference between the two groups was statistically significant(χ^(2)=4.547,P<0.05).After treatment,the hemorheology indexes of the observation group were significantly better than the control group in terms of red blood cell backlog(42.05±7.22)%,plasma viscosity(203.08±15.46)mPa·s,and erythrocyte sedimentation rate(18.35±3.28)mm/h.The difference was statistically significant(t=4.630,3.380,2.990,P<0.05).In the observation group,APTT(22.05±4.22)s,FIB(3.18±0.66)g/L,D-D(186.35±34.28)ng/mL,and PT(15.19±1.06)s of the observation group were significantly better than those of the control group.The difference between the two groups was statistically significant(t=2.051,6.976,3.348,4.721,P<0.05).The incidence of adverse reactions in the observation group(12.50%)was significantly better than that in the control group(37.50%),and the difference between the two groups was statistically significant(χ^(2)=4.000,P<0.05).Conclusion Naoxintong capsule combined with defibrase has an ideal clinical effect when applied to acute cerebral thrombosis.It can effectively improve the blood rheology indexes and coagulation function of patients.The incidence of adverse reactions is low.It has high clinical application value and is worthy of popularization.