超声造影联合血清基质细胞衍生因子-1和磷酸化应激诱导蛋白1检测对卵巢癌的诊断价值

Diagnostic value of contrast-enhanced ultrasound combined with serum stromal cell-derived factor-1 and stress-induced phosphoprotein 1 for ovarian cancer

目的探讨超声造影联合血清基质细胞衍生因子-1(SDF-1)、磷酸化应激诱导蛋白1(STIP1)检测对卵巢癌的诊断价值。方法选择2018年4月至2020年4月新乡医学院第一附属医院收治的104例卵巢癌患者(观察组)和104例卵巢良性肿瘤患者(对照组)为研究对象。比较2组患者血清STIP1、SDF-1水平;以病理检查结果为金标准,评估超声造影检查和血清STIP1、SDF-1单独及联合检测对卵巢癌的诊断价值。结果观察组患者血清STIP1和SDF-1水平均显著高于对照组(P<0.05)。以SDF-1>3.47μg·L^(-1)、STIP1>2.32μg·L^(-1)作为阳性判定标准,超声造影联合SDF-1诊断卵巢癌的灵敏度显著高于血清SDF-1、STIP1单独诊断(P<0.05),超声造影联合SDF-1和STIP1诊断卵巢癌的灵敏度显著高于血清SDF-1、STIP1及超声造影单独诊断(P<0.05)。SDF-1联合STIP1、超声造影联合STIP1、超声造影联合SDF-1、超声造影联合SDF-1和STIP1诊断卵巢癌的特异度与超声造影、SDF-1、STIP1单独诊断比较差异无统计学意义(P>0.05)。结论超声造影检查和血清SDF-1、STIP1指标联合诊断卵巢癌的灵敏度高于各项单独诊断,三项联合检测对卵巢癌的诊断有一定的临床价值。

Objective To explore the diagnostic value of contrast-enhanced ultrasound combined with serum stromal cell-derived factor-1(SDF-1)and stress-induced phosphoprotein 1(STIP1)for ovarian cancer.Methods A total of 104 patients with ovarian cancer(observation group)and 104 patients with benign ovarian tumors(control group)admitted to the First Affiliated Hospital of Xinxiang Medical University from April 2018 to April 2020 were selected as the research objects.Serum STIP1 and SDF-1 levels of patients were compared between the two groups;pathological examination results were used as the gold standard to evaluate the diagnostic value of contrast-enhanced ultrasound and serum STIP1,SDF-1 detection alone and in combination for ovarian cancer.Results The serum STIP1 and SDF-1 levels of patients in the observation group were significantly higher than those in the control group(P<0.05).SDF-1>3.47μg·L^(-1) and STIP1>2.32μg·L^(-1) were used as positive criteria,the sensitivity of the combined detection of contrast-enhanced ultrasound and SDF-1 in the diagnosis of ovarian cancer was significantly higher than that of the separate detection of serum SDF-1 or STIP1(P<0.05),the sensitivity of the combined detection of contrast-enhanced ultrasound and SDF-1,STIP1 in the diagnosis of ovarian cancer was significantly higher than that of the separate detection of contrast-enhanced ultrasound or serum SDF-1,STIP1(P<0.05).There was no statistical difference in the specificity of diagnosing ovarian cancer between the combined detection of SDF-1 and STIP1,contrast-enhanced ultrasound and STIP1,contrast-enhanced ultrasound and SDF-1,contrast-enhanced ultrasound and SDF-1,STIP1 and the separate detection of contrast-enhanced ultrasound or serum SDF-1,STIP1(P>0.05).Conclusion The sensitivity of combined detection of contrast-enhanced ultrasound examination and serum SDF-1,STIP1 in the diagnosis of ovarian cancer was higher than that of the separate detection,and the three combined detections have certain clinical value in the diagnosis of ovarian cancer.