核孔复合物与干细胞稳态

Nuclear pore complex and stem cell homeostasis

作为细胞核质之间物质交换的通道,核孔复合物(NuclearPoreComplex,NPC)是由约30种核孔蛋白构成的复杂大分子复合物。NPC除了介导核质之间的物质运输外,还参与调节染色质结构以及基因表达等过程。干细胞稳态的维持对于组织器官再生修复以及机体的稳态具有重要作用。越来越多的研究表明,NPC以及核孔蛋白可以通过多种机制调节干细胞的增殖与分化,影响干细胞稳态。本文现对NPC及其对干细胞稳态影响的相关研究进行综述,以期为干细胞稳态的调节与维持提供新的思路。

As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex(NPC) is a macromolecular complex composed of about 30 nucleoporins. In addition to mediating nucleocytoplasmic transport, NPC can also regulate chromatin organization and gene expression. The maintenance of stem cell homeostasis plays an essential role in the regeneration and repair of tissues, organs, and body homeostasis.More and more studies have shown that NPC and nucleoporins can regulate stem cell proliferation and differentiation, and affect stem cell homeostasis. This article reviews the related research on NPC and its influence on stem cell homeostasis, hoping to provide new ideas for the regulation and maintenance of stem cell homeostasis.