乳腺癌分子分型用荧光分子影像探针

Fluorescence molecular imaging probes for molecular classification of breast cancer

目前,乳腺癌的临床诊断就是结合病理类型和分子分型(免疫组化)。该方法是有创的,而且不能原位、实时地展现关键生物分子与临床关键信息之间的关系。本文介绍了利用分子影像技术对乳腺癌进行分子分型检测的最新研究进展。荧光成像灵敏度高,且不过分依赖图像分析,只需相应的荧光分子探针,即可实时、定量或半定量、多通道地得到肿瘤组织分子分型信息。因此,研制安全高效、组织穿透力强的近红外荧光分子探针是未来荧光成像技术和乳腺癌分子分型研究的重点。

At present, clinical diagnosis of breast cancer is based on the combination of pathological types and molecular typing(immunohistochemistry). Yet, it is invasive and unable to show the relationship between key biological molecules and clinical key information in situ and in real time. This paper introduces the latest research progress of molecular classification of breast cancer using molecular imaging technology. Fluorescence imaging has high sensitivity and does not rely too much on image analysis. Thus, molecular classification information of breast cancer can be obtained in real time and multi-channel, quantitatively or semi quantitatively by using the corresponding fluorescent probes. Therefore, the development of safe and efficient near-infrared fluorescent molecular probes with strong tissue penetration is the focus of future fluorescence imaging technology and molecular classification of breast cancer.