化肝解毒汤联合复方甘草酸苷对慢性乙型病毒性肝炎患者肝功能及血清HA、LN水平的影响

Effect of Huagan Jiedu Decoction Combined with Compound Glycyrrhizin on Liver Function and Serum HA and LN Levels in Patients with Chronic Hepatitis B

目的探讨化肝解毒汤联合复方甘草酸苷对慢性乙型病毒性肝炎患者肝功能及血清HA、LN水平的影响。方法选取2018年7月—2019年7月收治的180例慢性乙型病毒性肝炎患者,以随机数字表法分为对照组(90例)和观察组(90例)。对照组给予复方甘草酸苷注射液治疗,观察组在对照组基础上加用化肝解毒汤治疗。30 d为一个疗程,2组治疗周期均为3个疗程。对比2组治疗前后胸肋不适、情绪抑郁、胃脘胀满积分,血清ALT、TBil、Alb及HA、LN水平。结果与治疗前比较,治疗后2组胸肋不适、情绪抑郁、胃脘胀满积分及血清ALT、TBil、HA、LN水平均降低,且观察组低于对照组;而血清Alb水平升高,且观察组高于对照组(均P<0.05)。结论化肝解毒汤联合复方甘草酸苷对慢性乙型病毒性肝炎有临床治疗意义,其可改善患者临床症状及肝功能,同时通过降低血清HA、LN水平,缓解肝纤维化,且疗效显著。

Objective To investigate the effect of Huagan Jiedu decoction combined with compound Glycyrrhizin on liver function and serum HA,LN levels in patients with chronic hepatitis B.Methods 180 patients with chronic hepatitis B in our hospital from July 2018 to July2019 were randomly divided into control group(n=90)and observation group(n=90).The control group was treated with compound glycyrrhizin injection,and the observation group was treated with Huagan Jiedu decoction on the basis of the control group.30 d was a course of treatment,and the treatment cycle of both groups was 3 courses.The chest and rib discomfort,depression,epigastric fullness score,serum ALT,TBIL,ALB,HA and LN levels were compared between the two groups before and after treatment.Results Compared with before treatment,the chest rib discomfort,emotional depression,epigastric fullness score and serum ALT,TBIL,Ha,LN levels of the two groups were decreased,and the observation group was lower than the control group.The serum ALB level was increased,and the observation group was higher than the control group(All P<0.05).Conclusion Huagan Jiedu decoction combined with compound Glycyrrhizin has clinical significance in the treatment of chronic hepatitis B.It can improve the clinical symptoms and liver function of patients,and alleviate liver fibrosis by reducing the levels of serum HA and LN.