免疫耐受在牛乳过敏中的研究进展

Research Advances in Immune Tolerance in Cow's Milk Allergy

食物过敏是机体对过敏原产生的一种不良免疫反应,而免疫耐受是指机体对摄入的食物抗原不产生此类免疫应答。近年来,牛乳过敏的发生率越来越高,大部分牛乳过敏的儿童3岁之后出现了免疫耐受。基于此,介绍了牛乳过敏及引发免疫耐受的相关免疫细胞包括树突状细胞、调节性B细胞、调节性T细胞在免疫耐受中的作用及3种诱导免疫耐受的方法。

Food allergy is an adverse immune response that specific to food allergens,while immune tolerance is defined as the absence of such an immunological reaction to the ingested food antigens.The prevalence of cow's milk is increasing in recent years and most children allergic to cow's milk develop immune tolerance after three years old as reported.Based on these facts,the review introduces milk allergy and the related immune cells that trigger immune tolerance including dendritic cells,regulatory B cells and regulatory T cells,and their roles in immune tolerance.Three methods for inducing immune tolerance are also summarized.