雌激素水平与冠心病肾虚证的相关性及补肾中药的干预作用

Correlation between estrogen levels and coronary heart disease with kidney deficiency and intervention effect of kidney-tonifying traditional Chinese medicine

随着中国城市化的进程及人口老龄化的加剧,心血管疾病的负担日渐加重,绝经后妇女冠心病的发病率大大增加,研究发现绝经后妇女冠心病的发生与雌激素水平密切相关,但目前的治疗仍存在有效率低、副作用大的难点。肾虚证与生殖发育和整体机能具有较强的相关性,而绝经后冠心病患者的临床表现及特点符合中医的肾虚的病机,补肾法在绝经后冠心病患者的治疗中取得了良好的效果。该文通过总结临床及药理学证据,阐述了肾虚与雌激素水平的关系、补肾法治疗冠心病的病理机制,明确了补肾法临床疗效和优势,其可能成为预防和治疗绝经后冠心病的有效方法,并且有望更好地使冠心病患者受益。

With the process of urbanization and population aging in China, the burden of cardiovascular disease and the incidence of coronary heart disease among postmenopausal women have greatly increased. Studies have found that the incidence of coronary heart disease in postmenopausal women is closely related to the level of estrogen, but there are still difficulties of low efficiency and large side effects in current therapies. Kidney deficiency has a strong correlation with reproductive development and overall function. The clinical manifestations and characteristics of postmenopausal coronary heart disease patients conform to the pathogenesis of kidney deficiency in traditional Chinese medicine. The kidney-invigorating method has a good efficacy in treating postmenopausal coronary heart disease patients. This paper summarizes clinical and pharmacological evidences, expounds the relationship between kidney deficiency and the level of estrogen, and the pathological mechanism of the kidney-tonifying method in the treatment of coronary heart disease, and defines the clinical efficacy and advantages of the kidney-tonifying method. The method may become an effective method to prevent and treat postmenopausal coronary heart disease, and is expected to benefit patients with coronary heart disease better.