骨肉瘤预后相关的临床预测指标

The clinical predictors for the prognosis of patients with osteosarcoma

骨肉瘤是间叶组织起源的原发性骨恶性肿瘤,主要发生于儿童和青少年,具有恶性程度高、生长迅速、早期转移、预后较差等特点。当前,国内外的研究方向均主要集中在治疗上,但可靠的预测指标或评价系统对监测病情变化、指导治疗和预后评估等也非常重要。与骨肉瘤预后相关的临床预测指标较多,根据其特点可大致分为9大类,每类指标均有其优点和不足。充分认识和了解这些指标的特点,有针对性地选择应用,将有助于改善骨肉瘤的预后。

Osteosarcoma is a kind of primary malignant tumor of bone originated from mesenchymal tissue,which mainly occurs in children and adolescents,and presents the characteristics of high malignancy,rapid growth,early metastasis and poor prognosis.Currently,most of the studies at home and abroad mainly focused on therapeutic procedures.However,reliable prediction indices or evaluation systems are also pivotal for monitoring disease change,guiding treatment and evaluating prognosis.Multiple clinical predictors have been reported to be related to the prognosis of osteosarcoma,which can be roughly divided into 9 categories according to their characteristics.Each kind of predictor owns its inherent advantage and disadvantage,and full understanding of them and their characteristics can be helpful to improve the prognosis of osteosarcoma.