IL-39在急性冠状动脉综合征中的表达水平及意义

Expression level and significance of IL-39 in acute coronary syndrome

目的:探讨急性冠脉综合征(ACS)患者IL-39的表达水平及意义。方法:急性心肌梗死(AMI)60例、不稳定型心绞痛(UAP)38例和正常对照组52例共计150例患者均检测血清IL-39表达水平,研究其与IL-6、IL-35和左心室射血分数的相关性。结果:与对照组相比,ACS患者的血清IL-39水平显著降低,其IL-39与IL-35正相关(r=0.457,P<0.001),与IL-6负相关(r=-0.328,P<0.001)。在AMI组中,IL-39与AMI发作时间无相关性。结论:IL-39在ACS患者中表达水平降低,可能作为一种ACS抑制炎性因子。

Objective To investigate the expression level and significance of IL-39 in patients with acute coronary syndrome(ACS).Method Serum IL-39 expression level was detected in 150 patients,60 cases of acute myocardial infarction(AMI),28 cases of unstable angina pectoris(UAP)and 52 cases of normal control group.To study the correlation between IL-6,IL-35 and left ventricular ejection fraction.Results Serum IL-39 levels in ACS patients were significantly lower than those in the control group.IL-39 was positively correlated with IL-35(r=0.457,P<0.001),negatively correlated with IL-6(r=-0.328,P<0.001).In the AMI group,IL-39 was not associated with the onset time of AMI.Conclusion IL-39 expression level is decreased in patients with ACS,which may be used as an inflammatory factor to inhibit ACS.