细菌性肝脓肿患者引流液细菌培养及药敏试验结果分析

Analysis of the results of bacterial culture and drug sensitivity test in drainage fluid of patients with bacterial liver abscess

目的探究细菌性肝脓肿患者引流液细菌培养及药敏试验结果。方法选取细菌性肝脓肿患者102例,取引流液标本做细菌培养及药敏试验。结果102例细菌性肝脓肿患者共分离出病原菌102株,其中革兰阴性菌84株(82.35%),革兰阳性菌18株(17.65%);肺炎克雷伯杆菌对氨基糖苷类、氟喹诺酮类、替加环素、碳青霉烯类无耐药性,对头孢类、β-内酰胺酶抑制剂、头霉素类、磺胺类、单环β-内酰胺类敏感度较高,对氨苄西林、呋喃妥因耐药性高;大肠埃希菌对头霉素类(头孢西丁)、四环素类、碳青霉烯类、丁胺卡拉霉素敏感度较高;链球菌、肠球菌、溶血葡萄球菌对替加环素、万古霉素敏感度均为100%.结论细菌性肝脓肿患者病原菌主要为肺炎克雷伯菌,了解引流液细菌培养及药敏试验结果对指导临床抗生素应用具有重要意义。

Objective To explore the results of bacterial culture and drug sensitivity test in the drainage fluid of patients with bacterial liver abscess.Methods One hundred and two patients with bacterial liver abscess were selected,and drainage fluid samples were taken for bacterial culture and drug sensitivity test.Results A total of 102 pathogenic bacteria were isolated from 102 patients with bacterial liver abscess,including 84 gram-negative bacteria(82.35%)and 18 gram-positive bacteria(17.65%);Klebsiella pneumoniae was not resistant to aminoglycosides,fluoroquinolones,tigecycline,carbapenems,and was highly sensitive to cephalosporins,β-lactamase inhibitors,cephamicins,sulfonamides,and monocyclicβ-lactams,and highly resistance to ampicillin and nitrofurantoin;Escherichia coli was highly sensitive to cephalosporins(cephalosporin),tetracyclines,carbapenems,and amikaramycin;The sensitivity of Streptococcus,Enterococcus,and Staphylococcus haemolyticus to tigecycline and vancomycin were all 100%.Conclusion The main pathogen of patients with bacterial liver abscess is Klebsiella pneumoniae.Understanding the results of bacterial culture and drug susceptibility test in drainage fluid is of great significance for guiding clinical antibiotic application.