左甲状腺素钠联合放射性^(131)I治疗甲状腺乳头状癌术后的应用价值探讨

The Application Value of Levothyroxine Sodium Combined with Radioactive ^(131) I in the Treatment of Papillary Thyroid Carcinoma after Operation

目的分析左甲状腺素钠联合放射性^(131)I治疗甲状腺乳头状癌术后的应用价值探讨。方法选择该院2017年5月—2019年7月甲状腺乳头状癌术后患者98例,数字表随机分为两组,每组49例。对照组患者给予左甲状腺素钠治疗,观察组给予放射性^(131)I后再加用左甲状腺素钠。对上述两组患者进行术后1年复发率、转移率和病死率的比较,以及治疗前后患者SF-36生存质量评分、卡氏健康KPS评分。结果观察组术后1年复发率、转移率和病死率为2.04%(1例)、2.04%(1例)、0.00%(0例),低于对照组18.37%(9例)、16.33%(8例)、14.29%(7例),差异有统计学意义(χ^(2)=7.127、4.405、5.539,P<0.05);治疗前两组患者进行SF-36生存质量评分、卡氏健康KPS评分比较,差异无统计学意义(P>0.05),治疗后两组SF-36生存质量评分、卡氏健康KPS评分均改善,而观察组SF-36生存质量评分(85.51±6.24)分、卡氏健康KPS评分(82.19±6.40)分高于对照组(72.51±3.12)分、(75.21±6.21)分,差异有统计学意义(P<0.05)。结论左甲状腺素钠联合放射性^(131)I对于甲状腺乳头状癌术后的治疗效果确切,可有效降低术后1年复发率、转移率和病死率,并促进患者生存质量的提高。

Objective To analyze the application value of levothyroxine sodium combined with radioactive ^(131)I in the treatment of papillary thyroid carcinoma after surgery.Methods 98 patients with papillary thyroid carcinoma after surgery from May 2017 to July 2019 were selected in this hospital.The digital table was randomly divided into two groups,with 49 cases in each group.Patients in the control group were treated with levothyroxine sodium,and the observation group was treated with levothyroxine sodium after radioactive ^(131)I.The recurrence rate,metastasis rate and mortality rate of the above two groups of patients were compared at 1 year after the operation,as well as the SF-36 quality of life score and KPS score of KPS before and after treatment.Results The 1-year recurrence rate,metastasis rate and mortality rate of the observation group were 2.04%(1 case),2.04%(1 case),0.00%(0 case),which were lower than the control group 18.37%(9 cases),16.33%(8 cases),14.29%(7 cases),the difference was statistically significant(χ^(2)=7.127,4.405,5.539,P<0.05);before treatment,the two groups of patients were compared with the SF-36 quality of life score and the KPS score of Karnofsky’s health.The difference was not statistically significant(P>0.05).After treatment,the SF-36 quality of life scores and the KPS scores of Karnofsky's health were improved in the two groups,while the observation group's SF-36 quality of life scores(85.51±6.24)points and the KPS of Karnofsky's health were improved.The score(82.19±6.40)points was higher than the control group(72.51±3.12)points and(75.21±6.21)points,the difference was statistically significant(P<0.05).Conclusion Levothyroxine sodium combined with radioactive ^(131)I has a definite therapeutic effect on papillary thyroid carcinoma after surgery.It can effectively reduce the recurrence rate,metastasis rate and mortality rate of 1 year after surgery,and promote the improvement of the quality of life of patients.