口服补液盐Ⅲ联合双歧杆菌乳杆菌三联活菌片治疗儿童急性腹泻的效果评价

Evaluation of the Effect of Oral Rehydration SaltⅢCombined with Bifidobacterium and Lactobacillus Triple Viable Tablets in the Treatment of Children with Acute Diarrhea

目的探究儿童急性腹泻用口服补液盐Ⅲ联合双歧杆菌乳杆菌三联活菌片的治疗效果。方法 2018年6月—2019年7月,抽取100例该院收治的急性腹泻儿童进行分析,将100例患儿分为对照组(双歧杆菌乳杆菌三联活菌片治疗)、实验组(口服补液盐Ⅲ联合双歧杆菌乳杆菌三联活菌片治疗),各50例,对比治疗总效果、症状、体征消失及住院时间、肠道群菌分布情况。结果实验组治疗总效果98.0%高于对照组84.0%,差异有统计学意义(χ^(2)=4.396,P<0.05);实验组纠正脱水时间(0.99±0.17)d、住院时间(4.15±0.86)d短于对照组,且平均大便次数实验组(4.57±2.15)次/d少于对照组,差异有统计学意义(t=10.019、5.406、3.679,P<0.05);实验组双歧杆菌(9.26±1.24)cfu/g、肠杆菌(8.34±0.36)cfu/g、肠球菌(7.45±1.25)cfu/g、乳酸杆菌(6.81±1.11)cfu/g优于对照组,差异有统计学意义(t=5.135、13.665、5.971、3.437,P<0.05)。结论在儿童急性腹泻治疗中,应用口服补液盐Ⅲ联合双歧杆菌乳杆菌三联活菌片,既能缩短临床症状与体征缓解时间,又能改善肠道菌群分布情况,临床应用效果显著。

Objective To explore the therapeutic effect of oral rehydration saltⅢcombined with Lactobacillus bifidobacterium triple viable tablets for children with acute diarrhea.Methods From June 2018 to July 2019,100 children with acute diarrhea admitted to the hospital were selected for analysis.The 100 sick children were divided into control group(treatment with Lactobacillus bifidobacterium triple viable bacteria tablets)and experimental group(Oral rehydration salt Ⅲ combined with Lactobacillus bifidobacterium triple live bacteria tablets treatment),50 cases in each group,the total effect of the treatment,the disappearance of symptoms and signs,the length of stay in hospital,and the distribution of intestinal bacteria were compared.Results The total therapeutic effect of the experiment group was 98.0%higher than that of the control group 84.0%,and the difference was statistically significant(χ^(2)=4.396,P<0.05);the experiment group corrected dehydration time(0.99±0.17)d and hospitalization time(4.15±0.86)d were shorter than the control group,and the average number of stools in the experiment group(4.57±2.15)times/d was less than that in the control group,and the difference was statistically significant(t=10.019,5.406,3.677,P<0.05);the experiment group Bifidobacterium(9.26±1.24)cfu/g,Enterobacter(8.34±0.36)cfu/g,Enterococcus(7.45±1.25)cfu/g,Lactobacillus(6.81±1.11)cfu/g were better than the control group,and the difference was statistically significant(t=5.135,13.665,5.971,3.437,P<0.05).Conclusion In the treatment of children's acute diarrhea,the application of oral rehydration salt Ⅲ combined with Lactobacillus bifidobacterium triple live bacteria tablets can not only shorten the time for remission of clinical symptoms and signs,but also improve the intestinal flora.The clinical application effect is remarkable.