Dynamical analysis for delayed virus infection models with cell-to-cell transmission and density-dependent diffusion

In this paper,certain delayed virus dynamical models with cell-to-cell infection and density-dependent diffusion are investigated.For the viral model with a single strain,we have proved the well-posedness and studied the global stabilities of equilibria by defining the basic reproductive number R_(0) and structuring proper Lyapunov functional.Moreover,we found that the infection-free equilibrium is globally asymptotically stable if R_(0)<1,and the infection equilibrium is globally asymptotically stable if R_(0)>1.For the multi-strain model,we found that all viral strains coexist if the corresponding basic reproductive number R^(e)_(j)>1,while virus will extinct if R^(e)_(j)<1.As a result,we found that delay and the density-dependent diffusion does not influence the global stability of the model with cell-to-cell infection and homogeneous Neumann boundary conditions.