特发性快速眼球运动睡眠行为障碍表型转换早期预测指标的研究进展

Advances in early predictors for phenotypic transformation of idiopathic rapid eye movement sleep behavior disorder

特发性快速眼球运动睡眠行为障碍是帕金森病、路易体痴呆、多系统萎缩等α-突触核蛋白病的前驱阶段,因此及时识别转换为α-突触核蛋白病的早期预测指标是至关重要的。文中对特发性快速眼球运动睡眠行为障碍患者α-突触核蛋白相关的经典和新型早期预测指标的研究进展进行综述,有助于临床医生对早期疾病表型转换的认识。

Idiopathic rapid eye movement(REM)sleep behavior disorder is recognized as a prodromal stage ofα-synucleinopathies such as Parkinson′s disease,Lewy body dementia and multiple system atrophy.It is important to timely identify early predictors that can predict early conversion intoα-synucleinopathies.This review provided an update on classic and novel early predictors ofα-synucleinopathies in patients with idiopathic REM sleep behavior disorder and provided a comprehensive understanding on the phenotypic transformation of the disease.