PSMA PET在前列腺癌复发患者诊断及治疗中的应用

Application of PSMA PET in the diagnosis and treatment of recurrent prostate cancer

前列腺癌是老年男性中最常见的恶性肿瘤之一,由于我国人民寿命的延长及生活方式西化,其发病率逐年增高。随着根治性前列腺切除术(RP)和根治性放疗(RT)的普及,患者的预后得到了极大的改善,但仍有部分患者出现复发。常规的成像手段很难检测到早期的复发病变。近年来前列腺癌基于前列腺特异性膜抗原(PSMA)的正电子发射断层扫描(PET)进入人们的视线,这为前列腺癌复发患者的诊断和治疗提供了可选择的替代方案。本文将对当前PSMA PET在前列腺癌复发患者中的诊断、治疗方面的进展作一综述。

Prostate cancer is one of the most common malignant tumors in elderly men.Due to the prolongation of life expectancy and westernization of life style,its incidence rate is increasing year by year.With the popularization of radical prostatectomy(RP)and radical radiotherapy(RT),the prognosis of the patients has been greatly improved,but some patients still have recurrence.It is difficult to detect early recurrent lesions by conventional imaging techniques.In recent years,positron emission tomography(PET)based on prostate-specific membrane antigen(PSMA)has been introduced into people s vision,providing an alternative for the diagnosis and treatment of patients with recurrent prostate cancer.The progress of PSMA PET in the diagnosis and treatment of recurrent prostate cancer will be reviewed.