Effect of angiotensin(1-7)on angiotensin Ⅱ-induced vascular endothelial cell senescence by the p53/Drp1 pathway

Objective To observe the effect and mechanism of angiotensin (1-7) (Ang (1-7)) on angiotensin Ⅱ(Ang Ⅱ)-induced senescence of human umbilical vein endothelial cell(HUVEC).Methods HUVEC were cultured in vitro with DMEM high glucose medium containing 10% fetal bovine serum (FBS) for 48 hours and randomly divided into control group,Ang (1-7) group (1 μmol/L).