腹腔镜手术联合孕三烯酮治疗子宫内膜异位症合并不孕症的临床观察

Clinical observation of laparoscopic surgery combined with gestrinone in the treatment of endometriosis complicated with infertility

目的观察分析子宫内膜异位症合并不孕症患者在腹腔镜手术后口服孕三烯酮的临床疗效。方法96例行腹腔镜手术治疗的子宫内膜异位症合并不孕症患者作为研究对象,按照数字随机表法分为常规组和研究组,各48例。常规组患者给予单一腹腔镜手术治疗,研究组患者在腹腔镜手术后加用孕三烯酮治疗。对比两组临床治疗效果,治疗前后激素水平,6个月内妊娠率、复发率,不良反应发生情况。结果研究组患者的治疗总有效率为95.83%,明显高于常规组的83.33%,差异具有统计学意义(P<0.05)。治疗前,两组患者的雌二醇与促卵泡激素水平比较差异无统计学意义(P>0.05);治疗后,研究组患者的雌二醇与促卵泡激素水平均显著低于常规组,差异具有统计学意义(P<0.05)。研究组6个月内妊娠率93.75%高于常规组的77.08%,复发率2.08%低于常规组的14.58%,差异具有统计学意义(P<0.05)。研究组患者的不良反应发生率为6.25%,与常规组的8.33%对比,差异无统计学意义(P>0.05)。结论腹腔镜手术治疗子宫内膜异位症合并不孕症患者之后服用孕三烯酮,可进一步改善其激素水平,提高其妊娠率,降低其复发率,临床治疗效果确切、显著,不良反应未增加,值得引起临床重视并大范围借鉴推广。

Objective To observe and analyze the clinical efficacy of oral gestrinone after laparoscopic surgery in the treatment of endometriosis complicated with infertility.Methods A total of 96 cases of endometriosis complicated with infertility undergoing laparopscopic surgery as study subjects were divided into conventional group and research group according to random numerical table,with 48 cases in each group.The conventional group was treated with laparoscopic surgery only,and the research group was treated with laparoscopic surgery combined with gestrinone.The clinical effect,hormone levels before and after treatment,pregnancy rate within 6 months,recurrence rate and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the research group was 95.83%,which was obviously higher than 83.33%of the conventional group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in estradiol and follicle stimulating hormone between the two groups(P>0.05).After treatment,the estradiol and follicle stimulating hormone level of the research group were significantly lower than those of the conventional group,and the difference was statistically significant(P<0.05).The pregnancy rate within 6 months 93.75%of the research group was higher than 77.08%of the conventional group,and recurrence rate 2.08%was lower than 14.58%of conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the research group was 6.25%,which had no statistically significant difference compared with 8.33%of the conventional group(P>0.05).Conclusion Taking gestrinone after laparoscopic surgery in the treatment of endometriosis complicated with infertility can further improve the hormone level,increase the pregnancy rate and reduce the recurrence rate.The clinical treatment effect is exact and significant,and the adverse reactions are not increased.It is worthy of clinical attention and extensive reference and promotion.