常见中草药提取物及主要成分对细胞色素P4502C9抑制的研究进展

Research progress in the investigation of inhibitory effect of common Chinese herbal extracts and major components on Cytochrome P4502C9

近年来中草药常与西药联合使用,用于疾病的预防和治疗。中草药成分复杂,可能影响药物代谢酶活性,存在引发中草药-药物相互作用(HDI)的潜在风险。目前HDI尚未受到足够重视。I相药物代谢酶细胞色素P4502C9(CYP2C9)与超过15%的药物代谢相关,尤其是其底物包括几种治疗窗较窄的临床常用药物。关注中草药对该酶活性的影响,对HDI的评估至关重要。本文综述了包括银杏、人参、丹参、生姜和大蒜等在内的常见中草药的提取物及其主要活性成分对CYP2C9的抑制作用,旨在为临床中草药与西药的合理使用提供理论依据。

Chinese herbs and Western medicine are frequently applied in combination for disease treatment and prevention currently.The complicated components of Chinese Herbs may affect the activity of drug metabolism enzymes,and thus lead to herb-drug interaction(HDI).However,HDI has been neglected.Cytochrome P4502C9(CYP2C9),a phase I drug metabolism enzyme,is responsible for the metabolism of more than 15%drugs,including several narrow therapeutic window drugs.Evaluation of the CYP2C9 activity alteration is essential for HDI prediction.The current article reviewed the inhibitory effect on CYP2C9 of the common Chinese herbal extracts and major components,such as Ginkgo Biloba,Ginseng,Danshen,Ginger and Garlic.The aim is to provide theoretical basis for rational use of Chinese herbs and Western medicine in clinic.