胃苏颗粒联合四联疗法治疗脾胃气滞型Hp阳性慢性萎缩性胃炎的效果

Effect of Weisu Granules combined with quadruple therapy in the treatment of Hp positive chronic atrophic gastritis of the spleen and stomach with gas stagnation

目的探讨胃苏颗粒联合四联疗法治疗脾胃气滞型幽门螺杆菌(Hp)阳性慢性萎缩性胃炎的效果。方法选取淄博市博山区中医院2017年10月~2020年4月收治的116例脾胃气滞型Hp阳性慢性萎缩性胃炎患者,采用随机数字表法分为对照组(n=58)与观察组(n=58)。对照组采用四联疗法治疗,观察组在对照组的基础上联合胃苏颗粒治疗,观察并比较两组患者的治疗效果、中医临床症状积分改善情况以及不良反应总发生率。结果治疗后,观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的中医症状积分低于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论胃苏颗粒联合四联疗法治疗脾胃气滞型Hp阳性慢性萎缩性胃炎的效果较好,安全性高,值得推广应用。

Objective To investigate the effect of Weisu Granules combining with quadruple therapy in the treatment of Helicobacter pylori(Hp)positive chronic atrophic gastritis of the spleen and stomach with gas stagnation.Methods A total of 116 cases of Hp positive chronic atrophic gastritis of the spleen and stomach with gas stagnation admitted to Hospital of Traditional Chinese Medicine of Boshan District of Zibo City from October 2017 to April 2020 were selected and divided into the control group(n=58)and the observation group(n=58)according to the random number table method.The control group was treated with quadruple therapy,while the observation group was treated with Weisu Granules on the basis of the control group.The treatment effect,the improvement of traditional Chinese medicine of clinical symptom score and the total incidence of adverse reactions were observed and compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The traditional Chinese medicine of symptom score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Weisu Granules combined with quadruple therapy in the treatment of Hp positive chronic atrophic gastritis of the spleen and stomach with gas stagnation has better effect and high safety,which is worthy of popularization and application.